CKDdb-logoCKDdb - Molecule ID A5704

geneASPA, ACY2, ASP
nameAspartoacylase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACY2_HUMANP45381ENSG00000108381443Hs.171142271900, 608034

Functions and classifications

GOC:cytoplasm, C:nucleus, F:aminoacylase activity, F:aspartoacylase activity, F:hydrolase activity, acting on ester bonds, F:metal ion binding, P:aspartate catabolic process, P:central nervous system myelination, P:positive regulation of oligodendrocyte differentiation, F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
UniProt3D-structure, Complete proteome, Cytoplasm, Disease mutation, Hydrolase, Leukodystrophy, Metal-binding, Nucleus, Reference proteome, Zinc
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.320.01cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.30.03cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.30.00656RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.440.000113537RNA microarray20019191
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)0.69 nLC-ESI-UHR-QToF-MS/MS23344851
Exp24172336Mus musculus6kidneycortexAKI (AKI)2.240.005325151LC-MS/MS24172336
Exp24798088Rattus norvegicus kidney AKI (AKI)4.370.003MS/MS24798088

Compile date 08-10-2018© iMODE-CKD consortium