CKDdb-logoCKDdb - Molecule ID A5696

geneACSL5, ACS5, FACL5
nameLong-chain-fatty-acid--CoA ligase 5
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACSL5_HUMANQ9ULC5ENSP0000034622351703Hs.11638605677

Functions and classifications

GOC:endoplasmic reticulum, C:endoplasmic reticulum membrane, C:integral component of membrane, C:mitochondrial inner membrane, C:mitochondrial outer membrane, C:mitochondrion, F:ATP binding, F:long-chain fatty acid-CoA ligase activity, P:long-chain fatty acid metabolic process, P:long-chain fatty-acyl-CoA biosynthetic process, P:regulation of extrinsic apoptotic signaling pathway, P:triglyceride biosynthetic process, F:ligase activity, C:integral to membrane, P:cellular response to insulin stimulus, P:fatty acid transport, P:positive regulation of plasma membrane long-chain fatty acid transport, P:positive regulation of triglyceride biosynthetic process, P:regulation of apoptotic process, P:response to cholesterol, P:response to glucose stimulus, P:response to nutrient, P:response to sucrose stimulus
UniProtAcetylation, Alternative splicing, ATP-binding, Complete proteome, Endoplasmic reticulum, Fatty acid metabolism, Ligase, Lipid metabolism, Magnesium, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Reference proteome, Signal-anchor, Transmembrane, Transmembrane helix
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis) 2.931.25E-05RNA microarray  20019191
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease) 3.95< 0.05RNA microarray  21752957
Exp25770168Homo sapiens17bloodmononuclear cellsGlomerulonephritis (IgA nephropathy) 0.190.005RNA microarray  25770168

Compile date 08-30-2016© iMODE-CKD consortium