CKDdb-logoCKDdb - Molecule ID A5695

geneACSL4, ACS4, FACL4
nameLong-chain-fatty-acid--CoA ligase 4
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACSL4_HUMANO60488ENSP000003397872182Hs.268785300157, 300194, 300387

Functions and classifications

GOC:endoplasmic reticulum membrane, C:integral component of membrane, C:lipid particle, C:mitochondrial outer membrane, C:neuronal cell body, C:peroxisomal membrane, F:arachidonate-CoA ligase activity, F:ATP binding, F:long-chain fatty acid-CoA ligase activity, F:very long-chain fatty acid-CoA ligase activity, P:dendritic spine development, P:embryonic process involved in female pregnancy, P:fatty acid transport, P:lipid biosynthetic process, P:long-chain fatty-acyl-CoA biosynthetic process, P:negative regulation of prostaglandin secretion, P:positive regulation of cell growth, P:response to interleukin-15, P:response to nutrient, P:triglyceride biosynthetic process, F:catalytic activity, C:mitochondrial membrane, C:peroxisome, P:long-chain fatty acid metabolic process, P:triglyceride metabolic process, F:ligase activity, C:integral to membrane, C:endoplasmic reticulum
UniProtAlport syndrome, Alternative splicing, ATP-binding, Complete proteome, Deafness, Disease mutation, Elliptocytosis, Endoplasmic reticulum, Fatty acid metabolism, Hereditary hemolytic anemia, Ligase, Lipid metabolism, Magnesium, Membrane, Mental retardation, Microsome, Mitochondrion, Mitochondrion outer membrane, Nucleotide-binding, Peroxisome, Polymorphism, Reference proteome, Signal-anchor, Transmembrane, Transmembrane helix
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease) 6.25< 0.05RNA microarray  21752957
Exp24172336Mus musculus6kidneycortexAKI (AKI) 10000.0062007LC-MS/MS  24172336
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD) 0.240.013999RNA microarray  26317775

Compile date 08-30-2016© iMODE-CKD consortium