CKDdb-logoCKDdb - Molecule ID A5694

geneACSL3, ACS3, FACL3
nameLong-chain-fatty-acid--CoA ligase 3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACSL3_HUMANO95573ENSP000003500122181Hs.655772602371

Functions and classifications

GOC:endoplasmic reticulum, C:endoplasmic reticulum membrane, C:Golgi apparatus, C:integral component of membrane, C:lipid particle, C:mitochondrial outer membrane, C:perinuclear region of cytoplasm, C:peroxisomal membrane, F:ATP binding, F:long-chain fatty acid-CoA ligase activity, P:brain development, P:fatty acid biosynthetic process, P:long-chain fatty acid import, P:positive regulation of Golgi to plasma membrane protein transport, P:positive regulation of phosphatidylcholine biosynthetic process, P:positive regulation of secretion, P:response to nutrient, P:response to organic cyclic compound, P:very-low-density lipoprotein particle assembly, F:catalytic activity, F:ligase activity, C:integral to membrane, P:long-chain fatty-acyl-CoA biosynthetic process, P:triglyceride biosynthetic process, P:long-chain fatty acid metabolic process
UniProtATP-binding, Complete proteome, Endoplasmic reticulum, Fatty acid metabolism, Ligase, Lipid metabolism, Magnesium, Membrane, Microsome, Mitochondrion, Mitochondrion outer membrane, Nucleotide-binding, Peroxisome, Phosphoprotein, Polymorphism, Reference proteome, Signal-anchor, Transmembrane, Transmembrane helix
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp19845401Mus musculus32eyesretinaDiabetes (diabetic retinopathy) 2.95< 0.05LC-MS/MS  19845401
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease) 0.31< 0.05RNA microarray  21752957
Exp24316357Rattus norvegicus kidneyproximal tubule cellsureteral_obstruction (kidney obstruction in vitro model) 20.026179397LC-MS/MS  24316357
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD) 0.375.03E-06RNA microarray  26317775

Compile date 08-30-2016© iMODE-CKD consortium