CKDdb-logoCKDdb - Molecule ID A5693

geneACSL1, FACL1, FACL2
nameLong-chain-fatty-acid--CoA ligase 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACSL1_HUMANP33121ENSG000001517262180Hs.406678152425, 152426

Functions and classifications

GOC:endoplasmic reticulum membrane, C:integral component of membrane, C:mitochondrial outer membrane, C:peroxisomal membrane, C:plasma membrane, F:ATP binding, F:long-chain fatty acid-CoA ligase activity, P:adiponectin-activated signaling pathway, P:alpha-linolenic acid metabolic process, P:linoleic acid metabolic process, P:long-chain fatty acid import, P:long-chain fatty-acyl-CoA biosynthetic process, P:positive regulation of protein serine/threonine kinase activity, P:response to drug, P:response to nutrient, P:response to oleic acid, P:response to organic cyclic compound, P:triglyceride biosynthetic process, P:xenobiotic catabolic process, F:ligase activity, F:catalytic activity, C:endoplasmic reticulum, P:fatty acid transport, P:long-chain fatty acid metabolic process, P:triglyceride metabolic process, C:integral to membrane, P:adiponectin-mediated signaling pathway, P:regulation of fatty acid oxidation
UniProtAcetylation, Alternative splicing, ATP-binding, Complete proteome, Direct protein sequencing, Endoplasmic reticulum, Fatty acid metabolism, Ligase, Lipid metabolism, Magnesium, Membrane, Microsome, Mitochondrion, Mitochondrion outer membrane, Nitration, Nucleotide-binding, Peroxisome, Phosphoprotein, Reference proteome, Signal-anchor, Transmembrane, Transmembrane helix
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model) 2.850.05RNA microarray  17579666
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 0.310cDNA microarray  19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 0.50cDNA microarray  19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.410.000382RNA microarray  19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.440.000562RNA microarray  19698090
Exp19845401Mus musculus32eyesretinaDiabetes (diabetic retinopathy) 2.11< 0.05LC-MS/MS  19845401
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis) 1.553.59E-05RNA microarray  20019191

Compile date 08-30-2016© iMODE-CKD consortium