CKDdb-logoCKDdb - Molecule ID A5679

geneACOX1, ACOX
nameAcyl-coenzyme A oxidase 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACOX1_HUMANQ15067ENSG0000016153351Hs.464137264470, 609751

Functions and classifications

GOC:mitochondrion, C:peroxisomal matrix, C:peroxisomal membrane, F:acyl-CoA dehydrogenase activity, F:acyl-CoA oxidase activity, F:FAD binding, F:fatty acid binding, F:flavin adenine dinucleotide binding, F:palmitoyl-CoA oxidase activity, P:alpha-linolenic acid metabolic process, P:fatty acid beta-oxidation using acyl-CoA oxidase, P:fatty acid oxidation, P:generation of precursor metabolites and energy, P:lipid homeostasis, P:peroxisome fission, P:positive regulation of cholesterol homeostasis, P:prostaglandin metabolic process, P:spermatogenesis, P:very long-chain fatty acid metabolic process, C:peroxisome, P:fatty acid beta-oxidation
UniProtAcetylation, Alternative splicing, Complete proteome, Disease mutation, FAD, Fatty acid metabolism, Flavoprotein, Lipid metabolism, Oxidoreductase, Peroxisome, Phosphoprotein, Polymorphism, Reference proteome
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy) 0.74< 0.05cDNA microarray  17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy) 0.56< 0.05cDNA microarray  17003339
Exp17183245Homo sapiens24kidneyproximal tubuleproteinuria (proteinuric nephropathies) 0.16< 0.05cDNA microarrays  17183245
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.30.000528RNA microarray  19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.350.00719RNA microarray  19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.370.000393RNA microarray  19698090
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy) down MS/MS, LTQ LX linear ion trap  20093355
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease) 0.470.0439819RNA microarray  23935909
Exp24316357Rattus norvegicus kidneyproximal tubule cellsureteral_obstruction (kidney obstruction in vitro model) 2.090.00793548LC-MS/MS  24316357
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD) 0.130.013999RNA microarray  26317775

Compile date 08-30-2016© iMODE-CKD consortium