CKDdb-logoCKDdb - Molecule ID A5679

geneACOX1, ACOX
nameAcyl-coenzyme A oxidase 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACOX1_HUMANQ15067ENSG0000016153351Hs.464137264470, 609751

Functions and classifications

GOC:mitochondrion, C:peroxisomal matrix, C:peroxisomal membrane, F:acyl-CoA dehydrogenase activity, F:acyl-CoA oxidase activity, F:FAD binding, F:fatty acid binding, F:flavin adenine dinucleotide binding, F:palmitoyl-CoA oxidase activity, P:alpha-linolenic acid metabolic process, P:fatty acid beta-oxidation using acyl-CoA oxidase, P:fatty acid oxidation, P:generation of precursor metabolites and energy, P:lipid homeostasis, P:peroxisome fission, P:positive regulation of cholesterol homeostasis, P:prostaglandin metabolic process, P:spermatogenesis, P:very long-chain fatty acid metabolic process, C:peroxisome, P:fatty acid beta-oxidation
UniProtAcetylation, Alternative splicing, Complete proteome, Disease mutation, FAD, Fatty acid metabolism, Flavoprotein, Lipid metabolism, Oxidoreductase, Peroxisome, Phosphoprotein, Polymorphism, Reference proteome
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)0.74< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)0.56< 0.05cDNA microarray17003339
Exp17183245Homo sapiens24kidneyproximal tubuleproteinuria (proteinuric nephropathies)0.16< 0.05cDNA microarrays17183245
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.30.000528RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.350.00719RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.370.000393RNA microarray19698090
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)down MS/MS, LTQ LX linear ion trap20093355
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)0.470.0439819RNA microarray23935909
Exp24316357Rattus norvegicus kidneyproximal tubule cellsureteral_obstruction (kidney obstruction in vitro model)2.090.00793548LC-MS/MS24316357
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.130.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium