CKDdb-logoCKDdb - Molecule ID A5670

geneAco1, Ireb1, Irebp
nameCytoplasmic aconitate hydratase
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACOC_MOUSEP28271ENSMUSG0000002840511428Mm.331547100880

Functions and classifications

GOC:cytoplasm, C:cytosol, C:endoplasmic reticulum, C:Golgi apparatus, C:mitochondrion, F:4 iron, 4 sulfur cluster binding, F:aconitate hydratase activity, F:iron-responsive element binding, F:metal ion binding, P:cellular iron ion homeostasis, P:citrate metabolic process, P:intestinal absorption, P:post-embryonic development, P:regulation of gene expression, P:regulation of translation, P:response to iron(II) ion, P:tricarboxylic acid cycle, F:citrate hydro-lyase (cis-aconitate-forming) activity, F:isocitrate hydro-lyase (cis-aconitate-forming) activity, F:mRNA 5'-UTR binding
UniProt4Fe-4S, Complete proteome, Cytoplasm, Iron, Iron-sulfur, Lyase, Metal-binding, Reference proteome, RNA-binding, Tricarboxylic acid cycle
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.450.01cDNA microarray19099603
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.538.81E-05RNA microarray20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)down MS/MS, LTQ LX linear ion trap20093355
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)0.46 nLC-ESI-UHR-QToF-MS/MS23344851
Exp24262798aMus musculus kidneypodocytesnephropathies (collagen IV nephropathies)0.320.0001RNA microarray24262798
Exp24262798bMus musculus kidneypodocytesnephropathies (collagen IV nephropathies)0.330.0001RNA microarray24262798
Exp24316357Rattus norvegicus kidneyproximal tubule cellsureteral_obstruction (kidney obstruction in vitro model)00.000477786LC-MS/MS24316357
Exp24726496Rattus norvegicus kidneyglomeruliDiabetes (diabetic nephropathy)40.02LC-MS/MS24726496

Compile date 08-10-2018© iMODE-CKD consortium