CKDdb-logoCKDdb - Molecule ID A5662

geneACE2, UNQ868/PRO1885, UNQ868
nameAngiotensin-converting enzyme 2 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACE2_HUMANQ9BYF1ENSP0000025251959272Hs.178098300335

Functions and classifications

GOC:cell surface, C:extracellular space, C:integral component of membrane, C:membrane raft, C:plasma membrane, F:carboxypeptidase activity, F:endopeptidase activity, F:peptide hormone binding, F:virus receptor activity, F:zinc ion binding, P:angiotensin catabolic process in blood, P:angiotensin maturation, P:angiotensin-mediated drinking behavior, P:cellular protein metabolic process, P:positive regulation of reactive oxygen species metabolic process, P:proteolysis, P:receptor biosynthetic process, P:receptor-mediated virion attachment to host cell, P:regulation of cell proliferation, P:regulation of cytokine production, P:regulation of inflammatory response, P:regulation of vasoconstriction, P:regulation of vasodilation, P:viral entry into host cell, C:membrane, F:metallopeptidase activity, F:peptidyl-dipeptidase activity, C:cell surface, C:integral to membrane, F:metal ion binding, F:viral receptor activity, P:virion attachment, binding of host cell surface receptor
UniProt3D-structure, Alternative splicing, Carboxypeptidase, Cell membrane, Chloride, Complete proteome, Direct protein sequencing, Disulfide bond, Glycoprotein, Host-virus interaction, Hydrolase, Membrane, Metal-binding, Metalloprotease, Polymorphism, Protease, Reference proteome, Secreted, Signal, Transmembrane, Transmembrane helix, Zinc
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 0.430cDNA microarray  19099603
Exp19346236Homo sapiens10kidneycystsPolycystic_Kidney_Disease (Autosomal dominant polycystic kidney disease) 00.005mRNA microarray  19346236
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis) 1.291.50E-05RNA microarray  20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis) 1.374.60E-05RNA microarray  20019191
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy) 0.41< 0.05RNA-seq  23757392
Exp23757392bRattus norvegicus13kidneywholeDiabetes (diabetic nephropathy) 0.5< 0.05RNA-seq  23757392

Compile date 08-30-2016© iMODE-CKD consortium