CKDdb-logoCKDdb - Molecule ID A5661

geneACADSB
nameAcyl-CoA dehydrogenase, short/branched chain specific, mitochondrial precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACDSB_HUMANP45954ENSP0000035787336Hs.81934600301, 610006

Functions and classifications

GOC:mitochondrial matrix, F:acyl-CoA dehydrogenase activity, F:flavin adenine dinucleotide binding, P:branched-chain amino acid catabolic process, P:cellular nitrogen compound metabolic process, P:fatty acid metabolic process, C:mitochondrion, F:flavin adenine dinucleotide binding, F:oxidoreductase activity, acting on the CH-CH group of donors, F:electron carrier activity, F:short-branched-chain-acyl-CoA dehydrogenase activity, P:acyl-CoA metabolic process
UniProt3D-structure, Acetylation, Complete proteome, Disease mutation, FAD, Fatty acid metabolism, Flavoprotein, Lipid metabolism, Mitochondrion, Oxidoreductase, Polymorphism, Reference proteome, Transit peptide
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp17183245Homo sapiens24kidneyproximal tubuleproteinuria (proteinuric nephropathies) 0.18< 0.05cDNA microarrays  17183245
Exp19845401Mus musculus32eyesretinaDiabetes (diabetic retinopathy) 2.13< 0.05LC-MS/MS  19845401
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis) 1.533.59E-05RNA microarray  20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy) down MS/MS, LTQ LX linear ion trap  20093355
Exp24316357Rattus norvegicus kidneyproximal tubule cellsureteral_obstruction (kidney obstruction in vitro model) 00.00224883LC-MS/MS  24316357
Exp24726496Rattus norvegicus kidneyglomeruliDiabetes (diabetic nephropathy)   LC-MS/MS  24726496

Compile date 08-30-2016© iMODE-CKD consortium