CKDdb-logoCKDdb - Molecule ID A5655

geneACADM, MCAD
nameAcyl-CoA dehydrogenase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACADM_HUMANP11310ENSG0000011705434Hs.445040201450, 607008

Functions and classifications

GOC:axon, C:mitochondrial matrix, F:flavin adenine dinucleotide binding, F:identical protein binding, F:medium-chain-acyl-CoA dehydrogenase activity, P:cardiac muscle cell differentiation, P:carnitine biosynthetic process, P:carnitine metabolic process, CoA-linked, P:fatty acid beta-oxidation using acyl-CoA dehydrogenase, P:glycogen biosynthetic process, P:liver development, P:medium-chain fatty acid catabolic process, P:post-embryonic development, P:regulation of gluconeogenesis, P:response to cold, P:response to starvation, F:acyl-CoA dehydrogenase activity, F:flavin adenine dinucleotide binding, F:oxidoreductase activity, acting on the CH-CH group of donors, C:mitochondrion, F:oxidoreductase activity, acting on the CH-CH group of donors, C:mitochondrion, P:medium-chain fatty acid metabolic process, C:mitochondrial membrane, F:fatty-acyl-CoA binding, F:isomerase activity, P:protein homotetramerization, P:response to copper ion, P:response to drug, P:response to glucocorticoid stimulus, P:response to nutrient, C:mitochondrial matrix
UniProt3D-structure, Acetylation, Alternative splicing, Complete proteome, Direct protein sequencing, Disease mutation, FAD, Fatty acid metabolism, Flavoprotein, Lipid metabolism, Mitochondrion, Oxidoreductase, Polymorphism, Reference proteome, Transit peptide
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp17609286Mus musculus10kidneyglomeruliDiabetes (diabetic nephropathy in Type 1 diabetes)  < 0.05MALDI-TOF-MS  17609286
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 0.410.01cDNA microarray  19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 0.450.01cDNA microarray  19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 2.190.00134RNA microarray  19698090
Exp24090408Rattus norvegicus28kidneycortexChronic_Renal_Insufficiency (early_stage_CKD) down< 0.052DE, LC-MS/MS Western blotting24090408
Exp24434790Homo sapiens10kidneyglomeruliGlomerulonephritis (IgA nephropathy) 2.21< 0.05MALDI-TOF/TOF  24434790
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI) 0.320.0000208RNA microarray  24569379

Compile date 08-30-2016© iMODE-CKD consortium