CKDdb-logoCKDdb - Molecule ID A5654

geneACADL
nameAcyl-CoA dehydrogenase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACADL_HUMANP28330ENSG0000011536133Hs.471277201475, 609576, 201460

Functions and classifications

GOC:mitochondrial matrix, C:mitochondrial membrane, F:fatty-acyl-CoA binding, F:flavin adenine dinucleotide binding, F:long-chain-acyl-CoA dehydrogenase activity, F:palmitoyl-CoA oxidase activity, P:carnitine catabolic process, P:carnitine metabolic process, CoA-linked, P:fatty acid beta-oxidation using acyl-CoA dehydrogenase, P:long-chain fatty acid catabolic process, P:negative regulation of fatty acid biosynthetic process, P:negative regulation of fatty acid oxidation, P:protein homotetramerization, P:regulation of cholesterol metabolic process, P:temperature homeostasis
UniProtAcetylation, Complete proteome, FAD, Fatty acid metabolism, Flavoprotein, Lipid metabolism, Mitochondrion, Oxidoreductase, Polymorphism, Reference proteome, Transit peptide
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.390.0339RNA microarray  19698090
Exp19836472Mus musculus kidneytubule cellsDiabetes (Diabetic Nephropathy) 10.27 LC-MS/MS  19836472
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis) 1.343.23E-06RNA microarray  20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis) 1.345.52E-06RNA microarray  20019191
Exp20348205aRattus norvegicus10bloodplasmaDiabetes (Gestational Diabetes) 1.21< 0.001RP-nano-LC-ESI-MS/MS  20348205
Exp24316357Rattus norvegicus kidneyproximal tubule cellsureteral_obstruction (kidney obstruction in vitro model) 0.250.000382345LC-MS/MS  24316357

Compile date 08-30-2016© iMODE-CKD consortium