CKDdb-logoCKDdb - Molecule ID A5651

geneAbp1, Aoc1
nameAmiloride-sensitive amine oxidase [copper-containing]
speciesRattus norvegicus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AOC1_RATP36633ENSRNOG0000000857565029Rn.54493104610

Functions and classifications

GOC:extracellular space, C:plasma membrane, C:tight junction, F:cation channel activity, F:copper ion binding, F:diamine oxidase activity, F:drug binding, F:heparin binding, F:histamine oxidase activity, F:methylputrescine oxidase activity, F:primary amine oxidase activity, F:propane-1,3-diamine oxidase activity, F:protein complex binding, F:quinone binding, F:receptor activity, F:zinc ion binding, P:amine metabolic process, P:cation transport, P:cellular response to azide, P:cellular response to copper ion, P:cellular response to copper ion starvation, P:cellular response to histamine, P:oxidation-reduction process, P:response to antibiotic, P:response to drug, F:copper ion binding, F:primary amine oxidase activity, F:quinone binding, P:amine metabolic process, F:copper ion binding, F:primary amine oxidase activity, F:quinone binding, P:amine metabolic process
UniProtCalcium, Complete proteome, Copper, Disulfide bond, Glycoprotein, Heparin-binding, Metal-binding, Oxidoreductase, Reference proteome, Secreted, Signal, TPQ, Complete proteome, Copper, Metal-binding, Oxidoreductase, Reference proteome, TPQ,
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp15042541Homo sapiens4kidneyglomeruliDiabetes (diabetic nephropathy) 2.4< 0.01RNA microarray  15042541
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 0.430cDNA microarray  19099603
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 0.460.02cDNA microarray  19099603
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 5.010.02cDNA microarray  19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 0.420cDNA microarray  19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 3.270.01cDNA microarray  19099603
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis) 1.292.26E-05RNA microarray  20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy) down MS/MS, LTQ LX linear ion trap  20093355
Exp20181666aMus musculus6kidney IRI (ischemic injury model) 4.8< 0.05RNA microarray  20181666
Exp20181666bMus musculus6kidney IRI (ischemic injury model) 34.5< 0.05RNA microarray  20181666
Exp20181666cMus musculus6kidney IRI (ischemic injury model) 11< 0.05RNA microarray  20181666
Exp20813037cRattus norvegicus6kidneywholePolycystic_Kidney_Disease (polycystic kidney disease) 2.035.66E-08RNA microarray  20813037
Exp22970174Mus musculus8kidneywholeChronic_Renal_Insufficiency (mouse_CKD_model) 16.7< 0.05RNA microarray  22970174
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity) 0.140.000318RNA microarray  23291264
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity) 0.410.0117RNA microarray  23291264
Exp23326503Rattus norvegicus kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) 2.150.000000779mRNA microarray  23326503
Exp25957429Homo sapiens21urinewholeGlomerulonephritis (IgA nephropathy) 1.98<0.05nano-LC-MS/MS  25957429
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD) 20.090.003804RNA microarray  26317775

Compile date 08-30-2016© iMODE-CKD consortium