CKDdb-logoCKDdb - Molecule ID A5651

geneAbp1, Aoc1
nameAmiloride-sensitive amine oxidase [copper-containing]
speciesRattus norvegicus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AOC1_RATP36633ENSRNOG0000000857565029Rn.54493104610

Functions and classifications

GOC:extracellular space, C:plasma membrane, C:tight junction, F:cation channel activity, F:copper ion binding, F:diamine oxidase activity, F:drug binding, F:heparin binding, F:histamine oxidase activity, F:methylputrescine oxidase activity, F:primary amine oxidase activity, F:propane-1,3-diamine oxidase activity, F:protein complex binding, F:quinone binding, F:receptor activity, F:zinc ion binding, P:amine metabolic process, P:cation transport, P:cellular response to azide, P:cellular response to copper ion, P:cellular response to copper ion starvation, P:cellular response to histamine, P:oxidation-reduction process, P:response to antibiotic, P:response to drug, F:copper ion binding, F:primary amine oxidase activity, F:quinone binding, P:amine metabolic process, F:copper ion binding, F:primary amine oxidase activity, F:quinone binding, P:amine metabolic process
UniProtCalcium, Complete proteome, Copper, Disulfide bond, Glycoprotein, Heparin-binding, Metal-binding, Oxidoreductase, Reference proteome, Secreted, Signal, TPQ, Complete proteome, Copper, Metal-binding, Oxidoreductase, Reference proteome, TPQ,
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp15042541Homo sapiens4kidneyglomeruliDiabetes (diabetic nephropathy)2.4< 0.01RNA microarray15042541
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.430cDNA microarray19099603
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.460.02cDNA microarray19099603
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)5.010.02cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.420cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)3.270.01cDNA microarray19099603
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.292.26E-05RNA microarray20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)down MS/MS, LTQ LX linear ion trap20093355
Exp20181666aMus musculus6kidney IRI (ischemic injury model)4.8< 0.05RNA microarray20181666
Exp20181666bMus musculus6kidney IRI (ischemic injury model)34.5< 0.05RNA microarray20181666
Exp20181666cMus musculus6kidney IRI (ischemic injury model)11< 0.05RNA microarray20181666
Exp20813037cRattus norvegicus6kidneywholePolycystic_Kidney_Disease (polycystic kidney disease)2.035.66E-08RNA microarray20813037
Exp22970174Mus musculus8kidneywholeChronic_Renal_Insufficiency (mouse_CKD_model)16.7< 0.05RNA microarray22970174
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.140.000318RNA microarray23291264
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.410.0117RNA microarray23291264
Exp23326503Rattus norvegicus kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)2.150.000000779mRNA microarray23326503
Exp25957429Homo sapiens21urinewholeGlomerulonephritis (IgA nephropathy)1.98<0.05nano-LC-MS/MS25957429
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)20.090.003804RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium