CKDdb-logoCKDdb - Molecule ID A5650

geneABL1, ABL, JTK7
nameProto-oncogene tyrosine-protein kinase ABL1
speciesHomo sapiens

Molecule reference

ABL1_HUMANP00519ENSG0000009700725Hs.431048189980, 608232

Functions and classifications

GOC:actin cytoskeleton, C:cell leading edge, C:cytosol, C:mitochondrion, C:nuclear membrane, C:nucleolus, C:perinuclear region of cytoplasm, F:actin monomer binding, F:ATP binding, F:DNA binding, F:magnesium ion binding, F:manganese ion binding, F:nicotinate-nucleotide adenylyltransferase activity, F:non-membrane spanning protein tyrosine kinase activity, F:proline-rich region binding, P:actin cytoskeleton organization, P:autophagy, P:axon guidance, P:blood coagulation, P:cell adhesion, P:DNA damage induced protein phosphorylation, P:Fc-gamma receptor signaling pathway involved in phagocytosis, P:innate immune response, P:intrinsic apoptotic signaling pathway in response to DNA damage, P:mismatch repair, P:muscle cell differentiation, P:negative regulation of protein serine/threonine kinase activity, P:platelet-derived growth factor receptor signaling pathway, P:positive regulation of apoptotic process, P:positive regulation of muscle cell differentiation, P:positive regulation of oxidoreductase activity, P:positive regulation of peptidyl-tyrosine phosphorylation, P:regulation of actin cytoskeleton reorganization, P:regulation of autophagy, P:regulation of cell adhesion, P:regulation of cell cycle, P:regulation of cell motility, P:regulation of endocytosis, P:regulation of response to DNA damage stimulus, P:regulation of transcription, DNA-templated, P:signal transduction in response to DNA damage, C:nucleus, P:peptidyl-tyrosine phosphorylation, F:protein kinase activity, C:cytoplasm, C:actin cytoskeleton, P:endocytosis, P:regulation of transcription involved in S phase of mitotic cell cycle, P:signal transduction in response to DNA damage, F:kinase activity
UniProt3D-structure, Acetylation, Alternative splicing, Apoptosis, ATP-binding, Autophagy, Cell adhesion, Chromosomal rearrangement, Complete proteome, Cytoplasm, Cytoskeleton, DNA damage, DNA repair, DNA-binding, Endocytosis, Kinase, Lipoprotein, Magnesium, Manganese, Membrane, Metal-binding, Mitochondrion, Myristate, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Proto-oncogene, Reference proteome, SH2 domain, SH3 domain, Transferase, Tyrosine-protein kinase, Ubl conjugation
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.480.0186578RNA microarray19698090

Compile date 08-10-2018© iMODE-CKD consortium