CKDdb-logoCKDdb - Molecule ID A5634

geneAASS, LKR/SDH
nameAlpha-aminoadipate semialdehyde synthase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AASS_HUMANQ9UDR5ENSG0000000831110157Hs.156738238700, 605113

Functions and classifications

GOC:mitochondrial matrix, F:saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity, F:saccharopine dehydrogenase (NADP+, L-lysine-forming) activity, P:cellular nitrogen compound metabolic process, P:L-lysine catabolic process to acetyl-CoA via saccharopine, P:lysine catabolic process, P:protein tetramerization, F:oxidoreductase activity, C:mitochondrion, C:mitochondrion, P:L-lysine catabolic process, F:nucleotide binding, P:L-lysine catabolic process
UniProtAcetylation, Complete proteome, Mitochondrion, Multifunctional enzyme, NAD, NADP, Oxidoreductase, Reference proteome, Transit peptide
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 0.370cDNA microarray  19099603
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 0.420.01cDNA microarray  19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.360.0328RNA microarray  19698090
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease) 0.31< 0.05RNA microarray  21752957
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI) 0.410.000908RNA microarray  24569379

Compile date 08-30-2016© iMODE-CKD consortium