CKDdb-logoCKDdb - Molecule ID A5632

geneAadat, Kat2
nameKynurenine/alpha-aminoadipate aminotransferase, mitochondrial
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AADAT_MOUSEQ9WVM8ENSMUSG0000005722823923Mm.35020611754

Functions and classifications

GOC:mitochondrion, F:2-aminoadipate transaminase activity, F:kynurenine-oxoglutarate transaminase activity, F:pyridoxal phosphate binding, P:2-oxoglutarate metabolic process, P:biosynthetic process, P:glutamate metabolic process, P:kynurenine metabolic process, P:L-kynurenine metabolic process, P:L-lysine catabolic process to acetyl-CoA via saccharopine, P:tryptophan catabolic process to kynurenine
UniProtAcetylation, Aminotransferase, Complete proteome, Mitochondrion, Pyridoxal phosphate, Reference proteome, Transferase, Transit peptide
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)3.620.05RNA microarray17579666
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.210.01cDNA microarray19099603
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.240.01cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.190.03cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.220.04cDNA microarray19099603
Exp21544065bRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)1.270.004MALDI-TOF/TOF21544065
Exp21544065cRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)1.160.011MALDI-TOF/TOF21544065
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)0.47 nLC-ESI-UHR-QToF-MS/MS23344851
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.43< 0.05RNA-seq23757392
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.340.00187RNA microarray24569379
Exp24726496Rattus norvegicus kidneyglomeruliDiabetes (diabetic nephropathy)  LC-MS/MS24726496

Compile date 08-10-2018© iMODE-CKD consortium