CKDdb-logoCKDdb - Molecule ID A5630

geneAADAC, DAC
nameArylacetamide deacetylase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AAAD_HUMANP22760ENSG0000011477113Hs.506908600338

Functions and classifications

GOC:endoplasmic reticulum membrane, C:integral component of membrane, F:deacetylase activity, F:serine hydrolase activity, F:triglyceride lipase activity, P:positive regulation of triglyceride catabolic process, F:hydrolase activity, C:integral to membrane, F:carboxylesterase activity, F:retinyl-palmitate esterase activity
UniProtComplete proteome, Direct protein sequencing, Disulfide bond, Endoplasmic reticulum, Glycoprotein, Hydrolase, Membrane, Microsome, Polymorphism, Reference proteome, Signal-anchor, Transmembrane, Transmembrane helix
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.310cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.170.01cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.380.00937RNA microarray19698090
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.080.0000093RNA microarray23291264
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.46< 0.05RNA-seq23757392
Exp23760282aMus musculus kidneywholeureteral_obstruction (renal tubulointerstitial injury)2.260.012RNA microarray23760282
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.790.005325151LC-MS/MS24172336
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.298.34E-04RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium