CKDdb-logoCKDdb - Molecule ID A560E

geneAREG, SDGF, AREGB
nameAmphiregulin precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AREG_HUMANP15514ENSG00000109321374Hs.270833104640

Functions and classifications

GOC:cell surface, C:extracellular space, C:integral component of membrane, F:growth factor activity, P:cell proliferation, P:cell-cell signaling, P:epidermal growth factor receptor signaling pathway, P:G-protein coupled receptor signaling pathway, P:positive regulation of DNA replication, C:integral to membrane
UniProt3D-structure, Complete proteome, Cytokine, Direct protein sequencing, Disulfide bond, EGF-like domain, Glycoprotein, Growth factor, Membrane, Polymorphism, Reference proteome, Signal, Transmembrane, Transmembrane helix
PADBsignalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp18339188bHomo sapiens13bloodperipheral blood mononuclear cell (PBMC)Fabry (naive Fabry patients) 0.02867275microarray18339188
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)12.010.00000152RNA microarray19698090
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)0.242.10E-10NGS, RNA-seq.22266139
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.2< 0.05RNA-seq23757392
Exp23757392bRattus norvegicus13kidneywholeDiabetes (diabetic nephropathy)0.31< 0.05RNA-seq23757392

Compile date 08-10-2018© iMODE-CKD consortium