CKDdb-logoCKDdb - Molecule ID A559J

geneARHGEF5, TIM
nameRho guanine nucleotide exchange factor 5
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARHG5_HUMANQ12774ENSG000000503277984Hs.334600888

Functions and classifications

GOC:cytoplasm, C:plasma membrane, F:GTP binding, F:Rho guanyl-nucleotide exchange factor activity, P:actin cytoskeleton organization, P:intracellular signal transduction, P:myeloid dendritic cell chemotaxis, P:positive regulation of podosome assembly, P:positive regulation of Rho GTPase activity, P:regulation of Rho GTPase activity, F:phospholipid binding, C:intracellular, P:regulation of Rho protein signal transduction
UniProtAlternative splicing, Complete proteome, Guanine-nucleotide releasing factor, Phosphoprotein, Proto-oncogene, Reference proteome, SH3 domain
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.360.00334RNA microarray19698090
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)2.890.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium