CKDdb-logoCKDdb - Molecule ID A555E

geneAdam8, Ms2
nameDisintegrin and metalloproteinase domain-containing protein 8
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADAM8_MOUSEQ05910ENSMUSG0000002547311501Mm.15969602267

Functions and classifications

GOC:alpha9-beta1 integrin-ADAM8 complex, C:alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex, C:cell surface, C:cytoplasm, C:dense core granule membrane, C:integral component of plasma membrane, C:phagolysosome, C:plasma membrane, C:podosome, C:specific granule, C:tertiary granule, F:calcium ion binding, F:cell adhesion molecule binding, F:integrin binding, F:metalloendopeptidase activity, F:metallopeptidase activity, F:protein binding, F:zinc ion binding, P:activation of MAPK activity involved in innate immune response, P:angiogenesis, P:blood vessel endothelial cell migration, P:cell morphogenesis, P:cell-matrix adhesion, P:cellular response to hypoxia, P:leukocyte migration involved in inflammatory response, P:lymphocyte chemotaxis, P:membrane fusion, P:negative regulation of neuron apoptotic process, P:negative regulation of thymocyte aggregation, P:osteoclast fusion, P:positive regulation of acute inflammatory response, P:positive regulation of bone resorption, P:positive regulation of cell adhesion, P:positive regulation of cellular extravasation, P:positive regulation of eosinophil migration, P:positive regulation of fibronectin-dependent thymocyte migration, P:positive regulation of inflammatory response, P:positive regulation of membrane protein ectodomain proteolysis, P:positive regulation of neutrophil extravasation, P:positive regulation of NF-kappaB transcription factor activity, P:positive regulation of protein kinase B signaling, P:positive regulation of T cell differentiation in thymus, P:positive regulation of T cell migration, P:positive regulation of thymocyte apoptotic process, P:positive regulation of tumor necrosis factor (ligand) superfamily member 11 production, P:regulation of cell-cell adhesion, P:regulation of osteoclast differentiation, P:single organismal cell-cell adhesion, P:tissue morphogenesis, P:inflammatory response, P:integrin-mediated signaling pathway, C:plasma membrane, F:metalloendopeptidase activity, F:metallopeptidase activity, F:zinc ion binding, P:single organismal cell-cell adhesion, C:plasma membrane, F:metalloendopeptidase activity, F:metallopeptidase activity, F:zinc ion binding, P:single organismal cell-cell adhesion, C:plasma membrane, F:metallopeptidase activity, P:proteolysis, P:single organismal cell-cell adhesion, C:plasma membrane, F:metalloendopeptidase activity, F:metallopeptidase activity, F:zinc ion binding, P:single organismal cell-cell adhesion, C:plasma membrane, F:metalloendopeptidase activity, F:metallopeptidase activity, P:single organismal cell-cell adhesion, C:plasma membrane, F:metalloendopeptidase activity, F:metallopeptidase activity, F:zinc ion binding, P:single organismal cell-cell adhesion, C:plasma membrane, F:metalloendopeptidase activity, F:metallopeptidase activity, F:zinc ion binding, P:single organismal cell-cell adhesion, C:plasma membrane, F:metallopeptidase activity, P:integrin-mediated signaling pathway, P:proteolysis, P:single organismal cell-cell adhesion, C:plasma membrane, F:metalloendopeptidase activity, F:metallopeptidase activity, F:zinc ion binding, P:integrin-mediated signaling pathway, P:single organismal cell-cell adhesion, C:plasma membrane, F:metalloendopeptidase activity, F:metallopeptidase activity, F:zinc ion binding, P:single organismal cell-cell adhesion
UniProtComplete proteome, Disulfide bond, EGF-like domain, Glycoprotein, Hydrolase, Membrane, Metal-binding, Metalloprotease, Protease, Reference proteome, Signal, Transmembrane, Transmembrane helix, Zinc, Integrin
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)6.9< 0.05RNA microarray18187931
Exp18187931bMus musculus18kidneyglomeruliGlomerulonephritis (lupus nephritis)2.3< 0.05RNA microarray18187931
Exp21411733aMus musculus13macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)2.320cDNA microarray21411733
Exp21411733bMus musculus11macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.350cDNA microarray21411733
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.07< 0.05RNA microarray21752957
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)0.390.002462269NGS, RNA-seq.22266139
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)3.280.00000271RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium