CKDdb-logoCKDdb - Molecule ID A545F

geneBUB1B, BUBR1, MAD3L
nameMitotic checkpoint serine/threonine-protein kinase BUB beta
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BUB1B_HUMANO60566ENSG00000156970701Hs.513645176430, 257300, 602860

Functions and classifications

GOC:anaphase-promoting complex, C:condensed chromosome outer kinetochore, C:condensed nuclear chromosome kinetochore, C:cytosol, C:microtubule organizing center, C:perinuclear region of cytoplasm, C:spindle midzone, F:ATP binding, F:protein kinase activity, F:protein serine/threonine kinase activity, P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, P:apoptotic process, P:cell proliferation, P:metaphase/anaphase transition of mitotic cell cycle, P:mitosis, P:mitotic spindle assembly checkpoint, P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:phosphatidylinositol-mediated signaling, P:protein localization to chromosome, centromeric region, P:protein localization to kinetochore, P:spindle organization, C:anaphase-promoting complex, P:cell division, P:mitotic cell cycle spindle assembly checkpoint, P:mitotic metaphase/anaphase transition, P:mitotic prometaphase, P:spindle organization
UniProt3D-structure, Acetylation, Alternative splicing, Apoptosis, ATP-binding, Cell cycle, Cell division, Centromere, Chromosome, Complete proteome, Cytoplasm, Cytoskeleton, Disease mutation, Kinase, Kinetochore, Mitosis, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Serine/threonine-protein kinase, Transferase, Tumor suppressor, Ubl conjugation
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.280.00271RNA microarray19698090
Exp21411733bMus musculus11macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.390cDNA microarray21411733
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)3.360.0402254RNA microarray23935909
Exp25133636Homo sapiens22kidneyglomeruliGlomerulonephritis (IgA nephropathy (with endocapillary proliferation (E1)))3.610RNA microarray25133636

Compile date 08-10-2018© iMODE-CKD consortium