CKDdb-logoCKDdb - Molecule ID A544F

geneBUB1, BUB1L
nameMitotic checkpoint serine/threonine-protein kinase BUB1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BUB1_HUMANO43683ENSG00000169679699Hs.469649602452

Functions and classifications

GOC:condensed chromosome kinetochore, C:condensed nuclear chromosome, centromeric region, C:cytosol, F:ATP binding, F:protein kinase activity, F:protein serine/threonine kinase activity, P:apoptotic process, P:cell proliferation, P:chromosome segregation, P:mitosis, P:mitotic cell cycle, P:mitotic spindle assembly checkpoint, P:positive regulation of intrinsic apoptotic signaling pathway, P:regulation of sister chromatid cohesion, P:viral process, C:condensed nuclear chromosome, centromeric region, C:kinetochore, P:mitotic spindle checkpoint, P:positive regulation of intrinsic apoptotic signaling pathway, F:kinase activity, F:transferase activity, transferring phosphorus-containing groups, P:metabolic process, P:cell division, P:mitotic cell cycle spindle assembly checkpoint, P:mitotic prometaphase, P:virus-host interaction, P:cell proliferation, F:transferase activity, transferring phosphorus-containing groups
UniProt3D-structure, Apoptosis, ATP-binding, Cell cycle, Cell division, Centromere, Chromosome, Chromosome partition, Complete proteome, Host-virus interaction, Kinase, Kinetochore, Mitosis, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Serine/threonine-protein kinase, Transferase, Ubl conjugation
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.20.0000118RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.230.000143RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.250.00258RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.320.0215RNA microarray19698090
Exp21411733bMus musculus11macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.370.001cDNA microarray21411733
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2.43< 0.05RNA-seq23757392
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.252.76E-03RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.140.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium