CKDdb-logoCKDdb - Molecule ID A514F

geneBMPR1B
nameBone morphogenetic protein receptor type IB precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BMR1B_HUMANO00238ENSG00000138696658Hs.598475112600, 603248, 609441

Functions and classifications

GOC:integral component of plasma membrane, C:receptor complex, F:ATP binding, F:metal ion binding, F:receptor signaling protein serine/threonine kinase activity, F:SMAD binding, F:transforming growth factor beta receptor activity, type I, F:transmembrane receptor protein serine/threonine kinase activity, P:BMP signaling pathway, P:cartilage condensation, P:chondrocyte differentiation, P:dorsal/ventral pattern formation, P:eye development, P:inflammatory response, P:intracellular signal transduction, P:limb morphogenesis, P:ovarian cumulus expansion, P:positive regulation of bone mineralization, P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors, P:positive regulation of osteoblast differentiation, P:retina development in camera-type eye, P:retinal ganglion cell axon guidance, P:signal transduction by phosphorylation, C:membrane, P:protein phosphorylation, P:retinal ganglion cell axon guidance, C:membrane, F:transforming growth factor beta-activated receptor activity, P:transmembrane receptor protein serine/threonine kinase signaling pathway, C:dendrite, C:integral to plasma membrane, C:neuronal cell body
UniProt3D-structure, Alternative splicing, ATP-binding, Chondrogenesis, Complete proteome, Disease mutation, Disulfide bond, Dwarfism, Kinase, Magnesium, Manganese, Membrane, Metal-binding, Nucleotide-binding, Polymorphism, Receptor, Reference proteome, Serine/threonine-protein kinase, Signal, Transferase, Transmembrane, Transmembrane helix
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.330.0028RNA microarray19698090
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.35< 0.05RNA microarray21752957

Compile date 08-10-2018© iMODE-CKD consortium