CKDdb-logoCKDdb - Molecule ID A510F

geneBMP6, VGR
nameBone morphogenetic protein 6 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BMP6_HUMANP22004ENSG00000153162654Hs.285671112266

Functions and classifications

GOC:cytoplasm, C:extracellular space, C:membrane-bounded vesicle, F:protein heterodimerization activity, P:BMP signaling pathway, P:cartilage development, P:cellular response to mechanical stimulus, P:endochondral ossification, P:eye development, P:growth, P:immune response, P:inflammatory response, P:kidney development, P:male genitalia development, P:osteoblast differentiation, P:positive regulation of aldosterone biosynthetic process, P:positive regulation of aldosterone secretion, P:positive regulation of bone mineralization, P:positive regulation of chondrocyte differentiation, P:positive regulation of DNA-dependent DNA replication, P:positive regulation of endothelial cell differentiation, P:positive regulation of endothelial cell proliferation, P:positive regulation of epithelial cell proliferation, P:positive regulation of neuron differentiation, P:positive regulation of osteoblast differentiation, P:positive regulation of pathway-restricted SMAD protein phosphorylation, P:positive regulation of protein secretion, P:positive regulation of transcription from RNA polymerase II promoter, P:response to activity, P:response to glucocorticoid, P:response to iron ion, P:response to magnesium ion, P:response to retinoic acid, P:skeletal system development, P:SMAD protein signal transduction, P:type B pancreatic cell development, C:extracellular region
UniProt3D-structure, Chondrogenesis, Cleavage on pair of basic residues, Complete proteome, Cytokine, Developmental protein, Differentiation, Disulfide bond, Glycoprotein, Growth factor, Osteogenesis, Polymorphism, Reference proteome, Secreted, Signal
PADBsignalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.260.00655RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.290.000231RNA microarray19698090

Compile date 08-10-2018© iMODE-CKD consortium