CKDdb-logoCKDdb - Molecule ID A508F

geneBMP2, BMP2A
nameBone morphogenetic protein 2 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BMP2_HUMANP12643ENSG00000125845650Hs.73853112261

Functions and classifications

GOC:cell surface, C:extracellular region, C:extracellular space, F:BMP receptor binding, F:phosphatase activator activity, F:protein heterodimerization activity, F:retinol dehydrogenase activity, F:SMAD binding, P:activation of MAPK activity, P:atrioventricular valve morphogenesis, P:BMP signaling pathway involved in heart induction, P:bone mineralization involved in bone maturation, P:branching involved in ureteric bud morphogenesis, P:cardiac epithelial to mesenchymal transition, P:cardiac muscle cell differentiation, P:cardiac muscle tissue morphogenesis, P:cellular response to BMP stimulus, P:cellular response to organic cyclic compound, P:chondrocyte differentiation, P:corticotropin hormone secreting cell differentiation, P:embryonic heart tube anterior/posterior pattern specification, P:endocardial cushion morphogenesis, P:extracellular matrix organization, P:growth, P:in utero embryonic development, P:inflammatory response, P:inner ear development, P:mesenchymal cell proliferation involved in ureteric bud development, P:negative regulation of aldosterone biosynthetic process, P:negative regulation of calcium-independent cell-cell adhesion, P:negative regulation of canonical Wnt signaling pathway, P:negative regulation of cardiac muscle cell differentiation, P:negative regulation of cell cycle, P:negative regulation of cell proliferation, P:negative regulation of cortisol biosynthetic process, P:negative regulation of insulin-like growth factor receptor signaling pathway, P:negative regulation of transcription from RNA polymerase II promoter, P:negative regulation of Wnt signaling pathway involved in heart development, P:Notch signaling pathway, P:odontogenesis of dentin-containing tooth, P:osteoblast differentiation, P:pathway-restricted SMAD protein phosphorylation, P:pericardium development, P:positive regulation of apoptotic process, P:positive regulation of astrocyte differentiation, P:positive regulation of bone mineralization, P:positive regulation of cartilage development, P:positive regulation of cell migration, P:positive regulation of endothelial cell proliferation, P:positive regulation of epithelial to mesenchymal transition, P:positive regulation of ERK1 and ERK2 cascade, P:positive regulation of fat cell differentiation, P:positive regulation of neuron differentiation, P:positive regulation of odontogenesis, P:positive regulation of osteoblast differentiation, P:positive regulation of osteoblast proliferation, P:positive regulation of p38MAPK cascade, P:positive regulation of pathway-restricted SMAD protein phosphorylation, P:positive regulation of phosphatase activity, P:positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus, P:positive regulation of Wnt signaling pathway by BMP signaling pathway, P:protein destabilization, P:proteoglycan metabolic process, P:regulation of odontogenesis of dentin-containing tooth, P:response to hypoxia, P:SMAD protein signal transduction, P:telencephalon regionalization, P:thyroid-stimulating hormone-secreting cell differentiation, P:bone mineralization, P:cell fate commitment, P:cellular response to growth factor stimulus, P:oxidation-reduction process, P:positive regulation of ossification, P:positive regulation of transcription from RNA polymerase II promoter, C:cytoplasm, C:membrane-bounded vesicle, C:protein complex, P:cartilage development, P:negative regulation of Wnt receptor signaling pathway involved in heart development, P:ovulation cycle, P:positive regulation of Wnt receptor signaling pathway by BMP signaling pathway, P:response to mechanical stimulus, P:response to retinoic acid, P:negative regulation of gene expression
UniProt3D-structure, Chondrogenesis, Cleavage on pair of basic residues, Complete proteome, Cytokine, Developmental protein, Differentiation, Disulfide bond, Glycoprotein, Growth factor, Osteogenesis, Pharmaceutical, Polymorphism, Reference proteome, Secreted, Signal
PADBsignalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp15042541Homo sapiens4kidneyglomeruliDiabetes (diabetic nephropathy)0.05< 0.01RNA microarray15042541
Exp15042541Homo sapiens4kidneyglomeruliDiabetes (diabetic nephropathy)0.12< 0.01RNA microarray15042541
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)3.5< 0.05RNA microarray18187931
Exp18187931bMus musculus18kidneyglomeruliGlomerulonephritis (lupus nephritis)4.6< 0.05RNA microarray18187931
Exp18354378Homo sapiens8kidneyepithelial cellsureteral_obstruction (unilateral ureteral obstruction)4.925 +/- 1.042< 0.05RNA microarray18354378
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.370.0131RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.40.0151RNA microarray19698090
Exp21411733aMus musculus13macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.460.005cDNA microarray21411733
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.09< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.11< 0.05RNA microarray21752957
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)2.340.00016RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium