CKDdb-logoCKDdb - Molecule ID A508F

geneBMP2, BMP2A
nameBone morphogenetic protein 2 precursor
speciesHomo sapiens

Molecule reference


Functions and classifications

GOC:cell surface, C:extracellular region, C:extracellular space, F:BMP receptor binding, F:phosphatase activator activity, F:protein heterodimerization activity, F:retinol dehydrogenase activity, F:SMAD binding, P:activation of MAPK activity, P:atrioventricular valve morphogenesis, P:BMP signaling pathway involved in heart induction, P:bone mineralization involved in bone maturation, P:branching involved in ureteric bud morphogenesis, P:cardiac epithelial to mesenchymal transition, P:cardiac muscle cell differentiation, P:cardiac muscle tissue morphogenesis, P:cellular response to BMP stimulus, P:cellular response to organic cyclic compound, P:chondrocyte differentiation, P:corticotropin hormone secreting cell differentiation, P:embryonic heart tube anterior/posterior pattern specification, P:endocardial cushion morphogenesis, P:extracellular matrix organization, P:growth, P:in utero embryonic development, P:inflammatory response, P:inner ear development, P:mesenchymal cell proliferation involved in ureteric bud development, P:negative regulation of aldosterone biosynthetic process, P:negative regulation of calcium-independent cell-cell adhesion, P:negative regulation of canonical Wnt signaling pathway, P:negative regulation of cardiac muscle cell differentiation, P:negative regulation of cell cycle, P:negative regulation of cell proliferation, P:negative regulation of cortisol biosynthetic process, P:negative regulation of insulin-like growth factor receptor signaling pathway, P:negative regulation of transcription from RNA polymerase II promoter, P:negative regulation of Wnt signaling pathway involved in heart development, P:Notch signaling pathway, P:odontogenesis of dentin-containing tooth, P:osteoblast differentiation, P:pathway-restricted SMAD protein phosphorylation, P:pericardium development, P:positive regulation of apoptotic process, P:positive regulation of astrocyte differentiation, P:positive regulation of bone mineralization, P:positive regulation of cartilage development, P:positive regulation of cell migration, P:positive regulation of endothelial cell proliferation, P:positive regulation of epithelial to mesenchymal transition, P:positive regulation of ERK1 and ERK2 cascade, P:positive regulation of fat cell differentiation, P:positive regulation of neuron differentiation, P:positive regulation of odontogenesis, P:positive regulation of osteoblast differentiation, P:positive regulation of osteoblast proliferation, P:positive regulation of p38MAPK cascade, P:positive regulation of pathway-restricted SMAD protein phosphorylation, P:positive regulation of phosphatase activity, P:positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus, P:positive regulation of Wnt signaling pathway by BMP signaling pathway, P:protein destabilization, P:proteoglycan metabolic process, P:regulation of odontogenesis of dentin-containing tooth, P:response to hypoxia, P:SMAD protein signal transduction, P:telencephalon regionalization, P:thyroid-stimulating hormone-secreting cell differentiation, P:bone mineralization, P:cell fate commitment, P:cellular response to growth factor stimulus, P:oxidation-reduction process, P:positive regulation of ossification, P:positive regulation of transcription from RNA polymerase II promoter, C:cytoplasm, C:membrane-bounded vesicle, C:protein complex, P:cartilage development, P:negative regulation of Wnt receptor signaling pathway involved in heart development, P:ovulation cycle, P:positive regulation of Wnt receptor signaling pathway by BMP signaling pathway, P:response to mechanical stimulus, P:response to retinoic acid, P:negative regulation of gene expression
UniProt3D-structure, Chondrogenesis, Cleavage on pair of basic residues, Complete proteome, Cytokine, Developmental protein, Differentiation, Disulfide bond, Glycoprotein, Growth factor, Osteogenesis, Pharmaceutical, Polymorphism, Reference proteome, Secreted, Signal

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp15042541Homo sapiens4kidneyglomeruliDiabetes (diabetic nephropathy)0.05< 0.01RNA microarray15042541
Exp15042541Homo sapiens4kidneyglomeruliDiabetes (diabetic nephropathy)0.12< 0.01RNA microarray15042541
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)3.5< 0.05RNA microarray18187931
Exp18187931bMus musculus18kidneyglomeruliGlomerulonephritis (lupus nephritis)4.6< 0.05RNA microarray18187931
Exp18354378Homo sapiens8kidneyepithelial cellsureteral_obstruction (unilateral ureteral obstruction)4.925 +/- 1.042< 0.05RNA microarray18354378
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.370.0131RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.40.0151RNA microarray19698090
Exp21411733aMus musculus13macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.460.005cDNA microarray21411733
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.09< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.11< 0.05RNA microarray21752957
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)2.340.00016RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium