CKDdb-logoCKDdb - Molecule ID A5077

geneBGN, SLRR1A
nameBiglycan precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
PGS1_HUMANP21810ENSG00000182492633Hs.821301870

Functions and classifications

GOC:cell surface, C:Golgi lumen, C:lysosomal lumen, C:proteinaceous extracellular matrix, C:sarcolemma, C:transport vesicle, F:extracellular matrix binding, F:extracellular matrix structural constituent, F:glycosaminoglycan binding, P:blood vessel remodeling, P:carbohydrate metabolic process, P:chondroitin sulfate biosynthetic process, P:chondroitin sulfate catabolic process, P:dermatan sulfate biosynthetic process, P:extracellular matrix organization, P:peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan, C:extracellular matrix, C:intracellular, C:intracellular part
UniProtComplete proteome, Direct protein sequencing, Disulfide bond, Extracellular matrix, Glycoprotein, Leucine-rich repeat, Polymorphism, Proteoglycan, Reference proteome, Repeat, Secreted, Signal
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.65< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.45< 0.05cDNA microarray17003339
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)2.4< 0.05RNA microarray18187931
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.170.02cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.30.00907RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.310.0136RNA microarray19698090
Exp20485333Homo sapiens20bloodwholeGlomerulonephritis (IgA nephropathy)0.420.00967RNA microarray20485333
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.3< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.32< 0.05RNA microarray21752957
Exp25769567Homo sapiens19kidneygraftsChronic_rejection (Chronic_rejection)1.75< 0.05ESI-TOF/TOF25769567

Compile date 08-10-2018© iMODE-CKD consortium