CKDdb-logoCKDdb - Molecule ID A5075

geneACAN, AGC1, CSPG1
nameAggrecan core protein precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
PGCA_HUMANP16112ENSG00000157766176Hs.2159155760, 165800, 608361, 612813

Functions and classifications

GOC:extracellular region, C:Golgi lumen, C:lysosomal lumen, C:proteinaceous extracellular matrix, F:carbohydrate binding, F:extracellular matrix structural constituent, F:hyaluronic acid binding, F:metal ion binding, P:carbohydrate metabolic process, P:cell adhesion, P:extracellular matrix organization, P:keratan sulfate biosynthetic process, P:keratan sulfate catabolic process, P:proteolysis, P:skeletal system development, F:calcium ion binding, C:basement membrane, P:cartilage condensation, P:chondrocyte development, P:collagen fibril organization, P:proteoglycan biosynthetic process, C:perineuronal net, P:chondroblast differentiation, P:multicellular organismal aging, P:negative regulation of cell migration, P:ossification, P:response to acidity, P:response to drug, P:response to glucose stimulus, P:response to gravity, P:response to mechanical stimulus, P:response to organic cyclic compound, P:response to radiation, P:spinal cord development
UniProt3D-structure, Alternative splicing, Calcium, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Dwarfism, EGF-like domain, Extracellular matrix, Glycoprotein, Immunoglobulin domain, Lectin, Metal-binding, Polymorphism, Proteoglycan, Reference proteome, Repeat, Secreted, Signal, Sushi
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.30.000065RNA microarray  19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.420.0249RNA microarray  19698090
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection) 0.3 LC-MS/MS  20543976
Exp24189015aHomo sapiens5bloodmononuclear cellshealthy (healthy) 3.30 +/- 1.36< 0.001RNA microarray  24189015
Exp24189015bHomo sapiens9bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease) 4.09 +/- 0.54< 0.001RNA microarray  24189015
Exp24189015cHomo sapiens10bloodmononuclear cellsDialysis (Peritoneal dialysis) 2.47 +/- 1.1< 0.001RNA microarray  24189015
Exp24189015dHomo sapiens17bloodmononuclear cellsDialysis (hemodialysis) 2.25 +/- 0.64< 0.001RNA microarray  24189015

Compile date 08-30-2016© iMODE-CKD consortium