CKDdb-logoCKDdb - Molecule ID A501F

geneBDKRB2, BKR2
nameB2 bradykinin receptor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BKRB2_HUMANP30411ENSG00000168398624Hs.654542113503

Functions and classifications

GOC:endosome, C:integral component of plasma membrane, F:bradykinin receptor activity, F:phosphatidylinositol phospholipase C activity, P:arachidonic acid secretion, P:inflammatory response, P:negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator, P:negative regulation of peptidyl-serine phosphorylation, P:positive regulation of cytosolic calcium ion concentration, P:regulation of vascular permeability, P:regulation of vasoconstriction, P:response to salt stress, P:smooth muscle contraction, P:transmembrane receptor protein tyrosine kinase signaling pathway, P:vasoconstriction, P:vasodilation, C:integral component of membrane, P:response to stress, C:integral to plasma membrane, P:acute inflammatory response to antigenic stimulus, P:cellular response to hypoxia, P:elevation of cytosolic calcium ion concentration, P:maintenance of blood-brain barrier, P:negative regulation of apoptotic process, P:negative regulation of blood pressure, P:negative regulation of cell proliferation, P:response to drug, C:integral to membrane
UniProtAlternative splicing, Cell membrane, Complete proteome, Direct protein sequencing, Disulfide bond, G-protein coupled receptor, Glycoprotein, Lipoprotein, Membrane, Palmitate, Phosphoprotein, Polymorphism, Receptor, Reference proteome, Transducer, Transmembrane, Transmembrane helix
PADBreceptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.140.0000258RNA microarray19698090
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.29< 0.05RNA microarray21752957
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)0.350.000134917NGS, RNA-seq.22266139

Compile date 08-10-2018© iMODE-CKD consortium