CKDdb-logoCKDdb - Molecule ID A498J

geneADAMTS3
nameA disintegrin and metalloproteinase with thrombospondin motifs 3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ATS3_HUMANO15072ENSG000001561409508Hs.590919605011

Functions and classifications

GOC:proteinaceous extracellular matrix, F:heparin binding, F:metalloendopeptidase activity, F:zinc ion binding, P:collagen catabolic process, P:collagen fibril organization, P:protein processing, P:proteolysis, F:peptidase activity, P:integrin-mediated signaling pathway, F:metal ion binding
UniProtCleavage on pair of basic residues, Complete proteome, Disulfide bond, Extracellular matrix, Glycoprotein, Heparin-binding, Hydrolase, Metal-binding, Metalloprotease, Polymorphism, Protease, Reference proteome, Repeat, Secreted, Signal, Zinc, Zymogen, Integrin
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionValidationPubMed/DOI
Exp17579666bMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)333.140.05RNA microarraysqRT-PCR17579666
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)2.040.05RNA microarraysqRT-PCR17579666
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.330.0121RNA microarray 19698090
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.291.84E-03RNA microarray 26317775

Compile date 08-10-2018© iMODE-CKD consortium