CKDdb-logoCKDdb - Molecule ID A480F

geneBCL10, CIPER, CLAP
nameB cell lymphoma/leukemia 10
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BCL10_HUMANO95999ENSG000001428678915Hs.193516156240, 603517

Functions and classifications

GOC:CBM complex, C:cytoplasmic microtubule, C:cytosol, C:immunological synapse, C:lysosome, C:membrane raft, C:nucleus, C:perinuclear region of cytoplasm, C:plasma membrane, F:NF-kappaB binding, F:protein kinase binding, F:transcription coactivator activity, F:ubiquitin binding, P:adaptive immune response, P:B cell apoptotic process, P:cell death, P:cellular defense response, P:cellular response to mechanical stimulus, P:Fc-epsilon receptor signaling pathway, P:immunoglobulin mediated immune response, P:innate immune response, P:interleukin-6 biosynthetic process, P:lymphotoxin A biosynthetic process, P:negative regulation of mature B cell apoptotic process, P:neural tube closure, P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, P:positive regulation of extrinsic apoptotic signaling pathway, P:positive regulation of I-kappaB kinase/NF-kappaB signaling, P:positive regulation of interleukin-8 biosynthetic process, P:positive regulation of mast cell cytokine production, P:positive regulation of NF-kappaB transcription factor activity, P:positive regulation of phosphorylation, P:positive regulation of protein ubiquitination, P:positive regulation of T cell activation, P:positive regulation of transcription, DNA-templated, P:protein homooligomerization, P:regulation of T cell receptor signaling pathway, P:response to food, P:response to fungus, P:response to molecule of bacterial origin, P:T cell apoptotic process, P:T cell receptor signaling pathway, P:toll-like receptor signaling pathway, C:intracellular, P:regulation of apoptotic process, P:apoptotic process, P:induction of apoptosis, P:positive regulation of I-kappaB kinase/NF-kappaB cascade, P:positive regulation of transcription, DNA-dependent
UniProt3D-structure, Acetylation, Apoptosis, Chromosomal rearrangement, Complete proteome, Cytoplasm, Disease mutation, Membrane, Phosphoprotein, Reference proteome, Tumor suppressor
PADBSIG: signalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.45.56E-05RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium