CKDdb-logoCKDdb - Molecule ID A4598

geneBMP4, BMP2B, DVR4
nameBone morphogenetic protein 4 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BMP4_HUMANP12644ENSG00000125378652Hs.68879112262, 600625, 607932

Functions and classifications

GOC:extracellular space, C:proteinaceous extracellular matrix, F:BMP receptor binding, F:chemoattractant activity, F:cytokine activity, F:heparin binding, P:activation of MAPKK activity, P:anterior/posterior axis specification, P:blood vessel endothelial cell proliferation involved in sprouting angiogenesis, P:BMP signaling pathway involved in heart induction, P:BMP signaling pathway involved in nephric duct formation, P:BMP signaling pathway involved in renal system segmentation, P:BMP signaling pathway involved in ureter morphogenesis, P:branching involved in prostate gland morphogenesis, P:branching involved in ureteric bud morphogenesis, P:bronchus development, P:bud dilation involved in lung branching, P:bud elongation involved in lung branching, P:cardiac septum development, P:cellular response to growth factor stimulus, P:chondrocyte differentiation, P:cloacal septation, P:common-partner SMAD protein phosphorylation, P:cranial suture morphogenesis, P:deltoid tuberosity development, P:dorsal/ventral neural tube patterning, P:embryonic cranial skeleton morphogenesis, P:embryonic digit morphogenesis, P:embryonic hindlimb morphogenesis, P:embryonic skeletal joint morphogenesis, P:endocardial cushion development, P:endochondral ossification, P:epithelial cell proliferation involved in lung morphogenesis, P:epithelial-mesenchymal cell signaling, P:erythrocyte differentiation, P:extracellular matrix organization, P:germ cell development, P:glomerular capillary formation, P:glomerular visceral epithelial cell development, P:inner ear receptor cell differentiation, P:intermediate mesodermal cell differentiation, P:lens induction in camera-type eye, P:lung alveolus development, P:lymphoid progenitor cell differentiation, P:macrophage differentiation, P:mammary gland formation, P:mesenchymal cell differentiation involved in kidney development, P:mesenchymal cell proliferation involved in ureter development, P:mesenchymal cell proliferation involved in ureteric bud development, P:mesenchymal to epithelial transition involved in metanephros morphogenesis, P:mesodermal cell fate determination, P:mesonephros development, P:metanephric collecting duct development, P:monocyte differentiation, P:negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway, P:negative regulation of branching involved in ureteric bud morphogenesis, P:negative regulation of cell proliferation involved in heart morphogenesis, P:negative regulation of chondrocyte differentiation, P:negative regulation of epithelial cell proliferation, P:negative regulation of glomerular mesangial cell proliferation, P:negative regulation of glomerulus development, P:negative regulation of immature T cell proliferation in thymus, P:negative regulation of MAP kinase activity, P:negative regulation of mesenchymal cell proliferation involved in ureter development, P:negative regulation of metanephric comma-shaped body morphogenesis, P:negative regulation of metanephric S-shaped body morphogenesis, P:negative regulation of mitosis, P:negative regulation of myoblast differentiation, P:negative regulation of prostatic bud formation, P:negative regulation of striated muscle tissue development, P:negative regulation of T cell differentiation in thymus, P:negative regulation of thymocyte apoptotic process, P:negative regulation of transcription from RNA polymerase II promoter, P:neural tube closure, P:neuron fate commitment, P:odontogenesis, P:odontogenesis of dentin-containing tooth, P:osteoblast differentiation, P:pituitary gland development, P:positive regulation of apoptotic process, P:positive regulation of BMP signaling pathway, P:positive regulation of bone mineralization, P:positive regulation of branching involved in lung morphogenesis, P:positive regulation of cardiac muscle fiber development, P:positive regulation of cartilage development, P:positive regulation of collagen biosynthetic process, P:positive regulation of DNA-dependent DNA replication, P:positive regulation of endothelial cell differentiation, P:positive regulation of endothelial cell migration, P:positive regulation of endothelial cell proliferation, P:positive regulation of ERK1 and ERK2 cascade, P:positive regulation of kidney development, P:positive regulation of neuron differentiation, P:positive regulation of osteoblast differentiation, P:positive regulation of pathway-restricted SMAD protein phosphorylation, P:positive regulation of SMAD protein import into nucleus, P:positive regulation of smooth muscle cell proliferation, P:positive regulation of transcription from RNA polymerase II promoter, P:post-embryonic development, P:protein localization to nucleus, P:pulmonary artery endothelial tube morphogenesis, P:regulation of branching involved in prostate gland morphogenesis, P:regulation of odontogenesis of dentin-containing tooth, P:regulation of smooth muscle cell differentiation, P:renal system process, P:secondary heart field specification, P:SMAD protein signal transduction, P:smoothened signaling pathway, P:specification of organ position, P:specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway, P:steroid hormone mediated signaling pathway, P:telencephalon development, P:telencephalon regionalization, P:tendon cell differentiation, P:trachea development, P:trachea formation, P:type B pancreatic cell development, P:ureter epithelial cell differentiation, P:ureter smooth muscle cell differentiation, C:extracellular region, P:growth, P:angiogenesis, P:heart development, P:negative regulation of gene expression, P:organ induction, P:positive regulation of cell proliferation, P:positive regulation of protein phosphorylation, P:regulation of smooth muscle cell proliferation, C:cytoplasm, C:membrane-bounded vesicle, P:cardiac muscle cell differentiation, P:cellular response to dexamethasone stimulus, P:negative regulation of oligodendrocyte differentiation, P:ovarian follicle development, P:positive regulation of branching involved in ureteric bud morphogenesis, P:response to estradiol stimulus, P:response to mechanical stimulus, P:response to retinoic acid, P:retina development in camera-type eye, P:tongue morphogenesis, P:hematopoietic progenitor cell differentiation, P:positive regulation of ossification
UniProtChondrogenesis, Cleavage on pair of basic residues, Complete proteome, Cytokine, Developmental protein, Differentiation, Disease mutation, Disulfide bond, Extracellular matrix, Glycoprotein, Growth factor, Microphthalmia, Osteogenesis, Polymorphism, Reference proteome, Secreted, Signal, Plasmid
PADBsignalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.370.00315RNA microarray19698090
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)0.420.00032202NGS, RNA-seq.22266139

Compile date 08-10-2018© iMODE-CKD consortium