CKDdb-logoCKDdb - Molecule ID A4580

geneAPC2, APCL
nameAdenomatous polyposis coli protein 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APC2_HUMANO95996ENSG0000011526610297Hs.446376612034

Functions and classifications

GOC:actin filament, C:catenin complex, C:cytoplasmic microtubule, C:Golgi apparatus, C:Golgi membrane, C:lamellipodium membrane, C:perinuclear region of cytoplasm, F:beta-catenin binding, P:negative regulation of canonical Wnt signaling pathway, P:negative regulation of catenin import into nucleus, P:Wnt signaling pathway, P:negative regulation of canonical Wnt receptor signaling pathway, P:Wnt receptor signaling pathway, P:negative regulation of Wnt signaling pathway
UniProtAlternative splicing, Cell membrane, Coiled coil, Complete proteome, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Microtubule, Polymorphism, Reference proteome, Repeat, Wnt signaling pathway
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.220.0000228RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.280.00081RNA microarray19698090
Exp24172336Mus musculus6kidneycortexAKI (AKI)10000.0062007LC-MS/MS24172336
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.351.53E-06RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.432.16E-04RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium