CKDdb-logoCKDdb - Molecule ID A4562

geneAIF1, G1, IBA1
nameAllograft inflammatory factor-1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AIF1_HUMANP55008ENSG00000204472199Hs.76364601833

Functions and classifications

GOC:actin filament, C:cytosol, C:lamellipodium, C:nucleus, C:perinuclear region of cytoplasm, C:phagocytic cup, C:ruffle membrane, F:actin filament binding, F:calcium ion binding, P:actin filament bundle assembly, P:actin filament polymerization, P:cellular response to interferon-gamma, P:inflammatory response, P:microglial cell activation, P:negative regulation of smooth muscle cell chemotaxis, P:negative regulation of smooth muscle cell proliferation, P:phagocytosis, engulfment, P:positive regulation of G1/S transition of mitotic cell cycle, P:positive regulation of monocyte chemotaxis, P:positive regulation of smooth muscle cell chemotaxis, P:positive regulation of smooth muscle cell proliferation, P:positive regulation of T cell migration, P:positive regulation of T cell proliferation, P:Rac protein signal transduction, P:ruffle assembly, C:cytoplasm, P:ruffle assembly, C:perikaryon, P:cellular response to extracellular stimulus, P:cellular response to hormone stimulus, P:negative regulation of apoptotic process, P:negative regulation of gene expression, P:positive regulation of muscle hyperplasia, P:positive regulation of nitric oxide biosynthetic process, P:positive regulation of protein phosphorylation, P:response to axon injury, P:response to electrical stimulus, C:ruffle, P:positive regulation of cell migration, P:response to cytokine stimulus
UniProt3D-structure, Acetylation, Actin-binding, Alternative splicing, Calcium, Cell membrane, Cell projection, Complete proteome, Cytoplasm, Cytoskeleton, Membrane, Metal-binding, Phosphoprotein, Polymorphism, Reference proteome, Repeat
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp15042541Homo sapiens4kidneyglomeruliDiabetes (diabetic nephropathy)0.08< 0.01RNA microarray15042541
Exp16686758aMus musculus6kidney Transplantation (Allograft Rejection allo. CBA D5)23< 0.01mRNA microarray16686758
Exp16686758bMus musculus6kidney Transplantation (Allograft Rejection iso.CBA D5)3.4< 0.01mRNA microarray16686758
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)13.8< 0.05RNA microarray18187931
Exp18187931bMus musculus18kidneyglomeruliGlomerulonephritis (lupus nephritis)5.1< 0.05RNA microarray18187931
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.440.00585RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)5.321.46E-10RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)5.373.16E-11RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)7.891.76E-11RNA microarray19698090
Exp20813037cRattus norvegicus6kidneywholePolycystic_Kidney_Disease (polycystic kidney disease)2.391.58E-11RNA microarray20813037
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)0.340.0459RNA microarray20847290
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)0.410.0369RNA microarray20847290
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)0.410.0538RNA microarray20847290
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)0.430.0886RNA microarray20847290
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)0.430.0912RNA microarray20847290
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)0.440.064RNA microarray20847290
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)0.450.0703RNA microarray20847290
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.11< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.13< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.13< 0.05RNA microarray21752957
Exp24172336Mus musculus6kidneycortexAKI (AKI)10000.049762673LC-MS/MS24172336
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.160.000395RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium