CKDdb-logoCKDdb - Molecule ID A4558

geneAdipoq
nameAdiponectin
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADIPO_MOUSEQ60994ENSMUSG0000002287811450Mm.3969125853, 605441, 612556

Functions and classifications

GOC:cell periphery, C:cell surface, C:collagen trimer, C:endoplasmic reticulum, C:extracellular space, C:perinuclear region of cytoplasm, F:hormone activity, F:identical protein binding, F:protein binding, F:receptor binding, F:sialic acid binding, P:adiponectin-activated signaling pathway, P:brown fat cell differentiation, P:cellular response to cAMP, P:cellular response to drug, P:cellular response to epinephrine stimulus, P:cellular response to insulin stimulus, P:circadian rhythm, P:detection of oxidative stress, P:fatty acid beta-oxidation, P:fatty acid oxidation, P:glucose homeostasis, P:glucose metabolic process, P:low-density lipoprotein particle clearance, P:membrane depolarization, P:membrane hyperpolarization, P:negative regulation of blood pressure, P:negative regulation of cell migration, P:negative regulation of DNA biosynthetic process, P:negative regulation of ERK1 and ERK2 cascade, P:negative regulation of fat cell differentiation, P:negative regulation of gluconeogenesis, P:negative regulation of granulocyte differentiation, P:negative regulation of heterotypic cell-cell adhesion, P:negative regulation of hormone secretion, P:negative regulation of I-kappaB kinase/NF-kappaB signaling, P:negative regulation of inflammatory response, P:negative regulation of intracellular protein transport, P:negative regulation of low-density lipoprotein particle receptor biosynthetic process, P:negative regulation of macrophage derived foam cell differentiation, P:negative regulation of macrophage differentiation, P:negative regulation of MAP kinase activity, P:negative regulation of metanephric mesenchymal cell migration, P:negative regulation of phagocytosis, P:negative regulation of platelet-derived growth factor receptor signaling pathway, P:negative regulation of platelet-derived growth factor receptor-alpha signaling pathway, P:negative regulation of protein autophosphorylation, P:negative regulation of receptor binding, P:negative regulation of smooth muscle cell migration, P:negative regulation of smooth muscle cell proliferation, P:negative regulation of synaptic transmission, P:negative regulation of transcription, DNA-templated, P:negative regulation of tumor necrosis factor production, P:negative regulation of tumor necrosis factor-mediated signaling pathway, P:positive regulation of blood pressure, P:positive regulation of cAMP-dependent protein kinase activity, P:positive regulation of cellular protein metabolic process, P:positive regulation of cholesterol efflux, P:positive regulation of fatty acid metabolic process, P:positive regulation of glucose import, P:positive regulation of glycogen (starch) synthase activity, P:positive regulation of I-kappaB kinase/NF-kappaB signaling, P:positive regulation of interleukin-8 production, P:positive regulation of metanephric glomerular visceral epithelial cell development, P:positive regulation of monocyte chemotactic protein-1 production, P:positive regulation of myeloid cell apoptotic process, P:positive regulation of peptidyl-tyrosine phosphorylation, P:positive regulation of protein kinase A signaling, P:positive regulation of protein phosphorylation, P:positive regulation of renal albumin absorption, P:positive regulation of signal transduction, P:protein heterotrimerization, P:protein homooligomerization, P:protein localization to plasma membrane, P:regulation of glucose metabolic process, P:response to activity, P:response to ethanol, P:response to glucocorticoid, P:response to glucose, P:response to hypoxia, P:response to linoleic acid, P:response to nutrient, P:response to sucrose, P:response to tumor necrosis factor, C:collagen, F:eukaryotic cell surface binding, P:negative regulation of eukaryotic cell surface binding, P:negative regulation of I-kappaB kinase/NF-kappaB cascade, P:negative regulation of transcription, DNA-dependent, P:positive regulation of I-kappaB kinase/NF-kappaB cascade, P:positive regulation of protein kinase A signaling cascade, P:response to glucose stimulus
UniProt3D-structure, Collagen, Complete proteome, Direct protein sequencing, Disulfide bond, Glycoprotein, Hormone, Hydroxylation, Reference proteome, Repeat, Secreted, Signal
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)4.240.05RNA microarray17579666
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)0.15< 0.001MALDI-TOF/TOF21544065
Exp23760282aMus musculus kidneywholeureteral_obstruction (renal tubulointerstitial injury)0.070.035RNA microarray23760282
Exp23975652Homo sapiens123urinewholeDiabetes (type 2 diabetes)1.340UPLC-Q-TOF-HDMS23975652
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)6.442.31E-06RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium