CKDdb-logoCKDdb - Molecule ID A4552

geneACTG1, ACTG
nameActin, cytoplasmic 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACTG_HUMANP63261ENSP0000033151471Hs.514581102560, 604717, 614583

Functions and classifications

GOC:cytoskeleton, C:cytosol, C:extracellular vesicular exosome, C:filamentous actin, C:myofibril, F:ATP binding, F:structural constituent of cytoskeleton, P:adherens junction organization, P:axon guidance, P:cell junction assembly, P:Fc-gamma receptor signaling pathway involved in phagocytosis, P:innate immune response, P:sarcomere organization, C:cytoplasm, C:axon, C:cortical cytoskeleton, C:postsynaptic density, P:axonogenesis, P:blood coagulation, P:cellular component movement, P:response to calcium ion
UniProtAcetylation, ATP-binding, Complete proteome, Cytoplasm, Cytoskeleton, Deafness, Direct protein sequencing, Disease mutation, Mental retardation, Methylation, Non-syndromic deafness, Nucleotide-binding, Oxidation, Polymorphism, Reference proteome, Phosphoprotein
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionValidationPubMed/DOI
Exp16083269Rattus norvegicus10bloodserumTransplantation (Acute Renal Allograft Rejection)up< 0.05SELDI-MS (CM10, Q10), MALDI-MS/MS 16083269
Exp18354378Homo sapiens8kidneyepithelial cellsureteral_obstruction (unilateral ureteral obstruction)0.2 +/- 1.919< 0.05RNA microarray 18354378
Exp18440303Rattus norvegicus20urineglycoproteinsGlomerulonephritis (adriamycin nephropathy and Thy1.1 induced glomerulonephritis)0 LC-MS/MS 18440303
Exp19369687Mus musculus kidneyproximal tubule cellsCyclosporine_A_induced (Ciclosporine A in vitro model)0.4< 0.007MALDI TOF/TOFWestern blot19369687
Exp21538912bMus musculus8kidneyglomeruliglomerular_disease (glomerular disease)1.530.0099MALDI-TOF/TOF 21538912
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)1.220.021MALDI-TOF/TOF 21544065
Exp21544065bRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)1.390.008MALDI-TOF/TOF 21544065
Exp21595033bHomo sapiens14urineexosomesGlomerulonephritis (basement membrane nephropathy)0.20.00141LC-MS/MS 21595033
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.11< 0.05RNA microarray 21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.15< 0.05RNA microarray 21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)4.75< 0.05RNA microarray 21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)5.58< 0.05RNA microarray 21752957
Exp24211404Homo sapiens16urineexosomeDiabetes (diabetic nephropathy)0.380.0000083LC-MS/MS 24211404
Exp25032130Homo sapiens11urinewholeGlomerulonephritis (focal segmental glomerulosclerosis)0.57 nano-flow LC-MS/MS 25032130

Compile date 08-10-2018© iMODE-CKD consortium