CKDdb-logoCKDdb - Molecule ID A4551

nameActin, alpha cardiac muscle 1
speciesHomo sapiens

Molecule reference

ACTC_HUMANP68032ENSG0000015925170Hs.118127102540, 612098, 612794, 613424

Functions and classifications

GOC:actomyosin, actin portion, C:cytosol, C:extracellular vesicular exosome, C:I band, F:ATP binding, F:ATPase activity, F:myosin binding, P:apoptotic process, P:cardiac muscle contraction, P:cardiac muscle tissue morphogenesis, P:cardiac myofibril assembly, P:heart contraction, P:muscle filament sliding, P:negative regulation of apoptotic process, P:response to drug, P:response to ethanol, P:skeletal muscle thin filament assembly, C:actin cytoskeleton, C:smooth muscle contractile fiber, P:regulation of blood pressure, P:skeletal muscle thin filament assembly, P:vascular smooth muscle contraction, C:cytoplasm, C:cytoskeleton, C:actomyosin, actin part
UniProtAcetylation, ATP-binding, Atrial septal defect, Cardiomyopathy, Complete proteome, Cytoplasm, Cytoskeleton, Disease mutation, Methylation, Muscle protein, Nucleotide-binding, Oxidation, Reference proteome
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)3.394.99E-22NGS, RNA-seq.22266139
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)1.5 nLC-ESI-UHR-QToF-MS/MS23344851
Exp24497609Rattus norvegicus kidneyglomeruliPuromycin_induced (Puromycin nephropathy model)1.52< 0.05LC-MS/MS24497609
Exp24798088Rattus norvegicus kidney AKI (AKI)0.280.05MS/MS24798088

Compile date 08-10-2018© iMODE-CKD consortium