CKDdb-logoCKDdb - Molecule ID A4548

geneACTB, PS1TP5BP1
nameActin, cytoplasmic 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACTB_HUMANP60709ENSP0000034996060Hs.520640102630, 243310, 607371

Functions and classifications

GOC:axon, C:cortical cytoskeleton, C:cytoskeleton, C:cytosol, C:extracellular vesicular exosome, C:MLL5-L complex, C:NuA4 histone acetyltransferase complex, C:postsynaptic density, C:ribonucleoprotein complex, F:ATP binding, F:structural constituent of cytoskeleton, P:'de novo' posttranslational protein folding, P:adherens junction organization, P:axon guidance, P:blood coagulation, P:cell junction assembly, P:Fc-gamma receptor signaling pathway involved in phagocytosis, P:innate immune response, C:cytoplasm, C:filamentous actin, C:myofibril, P:axonogenesis, P:sarcomere organization, C:protein complex, P:cellular component movement, P:response to calcium ion
UniProt3D-structure, Acetylation, ATP-binding, Complete proteome, Cytoplasm, Cytoskeleton, Deafness, Direct protein sequencing, Disease mutation, Dystonia, Mental retardation, Methylation, Nucleotide-binding, Oxidation, Polymorphism, Reference proteome, Ubl conjugation
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp16083269Rattus norvegicus10bloodserumTransplantation (Acute Renal Allograft Rejection)up< 0.05SELDI-MS (CM10, Q10), MALDI-MS/MS16083269
Exp17021608Rattus norvegicus12urineexosomeAKI (AKI)0.59< 0.05MALDI-TOF-TOF17021608
Exp17609286Mus musculus10kidneyglomeruliDiabetes (diabetic nephropathy in Type 1 diabetes) < 0.05MALDI-TOF-MS17609286
Exp20716515Homo sapiens kidneyproximal tubule epithelial cellFibrosis (TGFbeta in vitro model)1.380.0015MALDI-TOF20716515
Exp21354196Mus musculus24urinewholeCyclosporine_A_induced (cyclosporine A nephrotoxicity)16.81 MS/MS21354196
Exp21354196Mus musculus24urinewholeCyclosporine_A_induced (cyclosporine A nephrotoxicity)8.49 MS/MS21354196
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)5.08< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)2.85< 0.05RNA microarray21752957
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)0.82 nLC-ESI-UHR-QToF-MS/MS23344851
Exp24281856dRattus norvegicus urinewholeDiabetes (diabetic nephropathy)0.51 +/- 0.16 MALDI-TOF24281856
Exp24281856eRattus norvegicus urinewholehealthy (healthy)0.49 +/- 0.11 MALDI-TOF24281856
Exp25770168Homo sapiens17bloodmononuclear cellsGlomerulonephritis (IgA nephropathy)4.920.001RNA microarray25770168
Exp25770168Homo sapiens17bloodmononuclear cellsGlomerulonephritis (IgA nephropathy)5.280.005RNA microarray25770168
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.427.91E-05RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium