CKDdb-logoCKDdb - Molecule ID A4548

geneACTB, PS1TP5BP1
nameActin, cytoplasmic 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACTB_HUMANP60709ENSP0000034996060Hs.520640102630, 243310, 607371

Functions and classifications

GOC:axon, C:cortical cytoskeleton, C:cytoskeleton, C:cytosol, C:extracellular vesicular exosome, C:MLL5-L complex, C:NuA4 histone acetyltransferase complex, C:postsynaptic density, C:ribonucleoprotein complex, F:ATP binding, F:structural constituent of cytoskeleton, P:'de novo' posttranslational protein folding, P:adherens junction organization, P:axon guidance, P:blood coagulation, P:cell junction assembly, P:Fc-gamma receptor signaling pathway involved in phagocytosis, P:innate immune response, C:cytoplasm, C:filamentous actin, C:myofibril, P:axonogenesis, P:sarcomere organization, C:protein complex, P:cellular component movement, P:response to calcium ion
UniProt3D-structure, Acetylation, ATP-binding, Complete proteome, Cytoplasm, Cytoskeleton, Deafness, Direct protein sequencing, Disease mutation, Dystonia, Mental retardation, Methylation, Nucleotide-binding, Oxidation, Polymorphism, Reference proteome, Ubl conjugation
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp16083269Rattus norvegicus10bloodserumTransplantation (Acute Renal Allograft Rejection) up< 0.05SELDI-MS (CM10, Q10), MALDI-MS/MS  16083269
Exp17021608Rattus norvegicus12urineexosomeAKI (AKI) 0.59< 0.05MALDI-TOF-TOF  17021608
Exp17609286Mus musculus10kidneyglomeruliDiabetes (diabetic nephropathy in Type 1 diabetes)  < 0.05MALDI-TOF-MS  17609286
Exp20716515Homo sapiens kidneyproximal tubule epithelial cellFibrosis (TGFbeta in vitro model) 1.380.0015MALDI-TOF  20716515
Exp21354196Mus musculus24urinewholeCyclosporine_A_induced (cyclosporine A nephrotoxicity) 16.81 MS/MS  21354196
Exp21354196Mus musculus24urinewholeCyclosporine_A_induced (cyclosporine A nephrotoxicity) 8.49 MS/MS  21354196
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease) 5.08< 0.05RNA microarray  21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease) 2.85< 0.05RNA microarray  21752957
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy) 0.82 nLC-ESI-UHR-QToF-MS/MS  23344851
Exp24281856dRattus norvegicus urinewholeDiabetes (diabetic nephropathy) 0.51 +/- 0.16 MALDI-TOF  24281856
Exp24281856eRattus norvegicus urinewholehealthy (healthy) 0.49 +/- 0.11 MALDI-TOF  24281856
Exp25770168Homo sapiens17bloodmononuclear cellsGlomerulonephritis (IgA nephropathy) 4.920.001RNA microarray  25770168
Exp25770168Homo sapiens17bloodmononuclear cellsGlomerulonephritis (IgA nephropathy) 5.280.005RNA microarray  25770168
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD) 0.427.91E-05RNA microarray  26317775

Compile date 08-30-2016© iMODE-CKD consortium