CKDdb-logoCKDdb - Molecule ID A444F

geneAURKA, AIK, AIRK1
nameAurora kinase A
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AURKA_HUMANO14965ENSG000000875866790Hs.250822603072, 602687

Functions and classifications

GOC:cytosol, C:midbody, C:nucleus, C:perinuclear region of cytoplasm, C:spindle microtubule, C:spindle pole centrosome, F:ATP binding, F:protein serine/threonine kinase activity, F:protein serine/threonine/tyrosine kinase activity, P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, P:cell projection organization, P:mitosis, P:negative regulation of protein binding, P:phosphatidylinositol-mediated signaling, P:positive regulation of mitosis, P:protein autophosphorylation, P:regulation of centrosome cycle, P:regulation of protein stability, P:spindle organization, P:spindle stabilization, P:mitotic cell cycle, F:protein kinase activity, P:cell division, P:response to estradiol stimulus, C:centrosome, C:spindle
UniProt3D-structure, ATP-binding, Cell cycle, Cell division, Cilium biogenesis/degradation, Complete proteome, Cytoplasm, Cytoskeleton, Kinase, Microtubule, Mitosis, Nucleotide-binding, Phosphoprotein, Polymorphism, Proto-oncogene, Reference proteome, Serine/threonine-protein kinase, Transferase, Ubl conjugation
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.280.00727RNA microarray19698090
Exp24477687Mus musculus kidneywholeIRI (ischemia-reperfusion injury)3.840.0057RT-PCR24477687

Compile date 08-10-2018© iMODE-CKD consortium