CKDdb-logoCKDdb - Molecule ID A4425

geneCACNA1D, CACH3, CACN4
nameVoltage-dependent L-type calcium channel alpha-1D subunit
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CAC1D_HUMANQ01668ENSG00000157388776Hs.476358114206, 614896

Functions and classifications

GOC:voltage-gated calcium channel complex, C:Z disc, F:ankyrin binding, F:high voltage-gated calcium channel activity, F:metal ion binding, F:voltage-gated calcium channel activity involved in regulation of SA node cell action potential, P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway, P:axon guidance, P:calcium ion import, P:energy reserve metabolic process, P:membrane repolarization involved in regulation of SA node cell action potential, P:positive regulation of calcium ion transport, P:regulation of atrial cardiac muscle cell membrane repolarization, P:regulation of heart rate by cardiac conduction, P:regulation of insulin secretion, P:regulation of potassium ion transmembrane transporter activity, P:sensory perception of sound, P:small molecule metabolic process, F:voltage-gated calcium channel activity
UniProt3D-structure, Alternative splicing, Calcium, Calcium channel, Calcium transport, Complete proteome, Deafness, Disease mutation, Disulfide bond, Glycoprotein, Ion channel, Ion transport, Membrane, Metal-binding, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Transmembrane, Transmembrane helix, Transport, Triplet repeat expansion, Voltage-gated channel
PADBchannel

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.370.0067RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.370.0345RNA microarray19698090
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.11< 0.05RNA microarray21752957

Compile date 08-10-2018© iMODE-CKD consortium