CKDdb-logoCKDdb - Molecule ID A4420

geneAno6
nameAnoctamin-6
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ANO6_MOUSEQ6P9J9ENSMUSG00000064210105722Mm.38087262890, 608663

Functions and classifications

GOC:chloride channel complex, C:intracellular, C:plasma membrane, F:calcium activated cation channel activity, F:intracellular calcium activated chloride channel activity, F:phospholipid scramblase activity, F:protein homodimerization activity, F:voltage-gated ion channel activity, P:activation of blood coagulation via clotting cascade, P:blood coagulation, P:bone mineralization involved in bone maturation, P:calcium activated galactosylceramide scrambling, P:calcium activated phosphatidylcholine scrambling, P:calcium activated phosphatidylserine scrambling, P:calcium activated phospholipid scrambling, P:cation transport, P:chloride transmembrane transport, P:chloride transport, P:dendritic cell chemotaxis, P:phosphatidylserine exposure on blood platelet, P:phospholipid scrambling, F:chloride channel activity
UniProtAlternative splicing, Cell membrane, Chloride, Chloride channel, Complete proteome, Glycoprotein, Ion channel, Ion transport, Membrane, Reference proteome, Transmembrane, Transmembrane helix, Transport, Voltage-gated channel
PADBchannel

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)2.2< 0.05RNA microarray18187931
Exp18187931bMus musculus18kidneyglomeruliGlomerulonephritis (lupus nephritis)3.2< 0.05RNA microarray18187931
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.423.47E-05RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium