CKDdb-logoCKDdb - Molecule ID A4410

geneASIC2, ACCN1, ACCN
nameAmiloride-sensitive brain sodium channel BNaC1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ASIC2_HUMANQ16515ENSG0000010868440Hs.368417601784

Functions and classifications

GOC:dendritic spine, C:integral component of plasma membrane, C:neuronal cell body, C:synapse, F:ligand-gated sodium channel activity, F:voltage-gated sodium channel activity, P:central nervous system development, P:detection of mechanical stimulus involved in sensory perception, P:negative regulation of apoptotic process, P:peripheral nervous system development, P:phototransduction, P:positive regulation of synapse assembly, P:protein localization to synapse, P:regulation of membrane potential, P:regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback, P:regulation of vasoconstriction, P:response to acid, P:sensory perception of sound, P:synaptic transmission, P:sodium ion transmembrane transport, C:integral component of membrane, C:integral to plasma membrane, P:regulation of ion transmembrane transport, C:integral to membrane
UniProtAlternative splicing, Cell membrane, Complete proteome, Disulfide bond, Glycoprotein, Ion channel, Ion transport, Membrane, Polymorphism, Reference proteome, Sodium, Sodium channel, Sodium transport, Transmembrane, Transmembrane helix, Transport
PADBchannel

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.440.0152RNA microarray19698090
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)4.270.0246RNA microarray20847290

Compile date 08-10-2018© iMODE-CKD consortium