CKDdb-logoCKDdb - Molecule ID A439F

geneADAMTS5, ADAMTS11, ADMP2
nameA disintegrin and metalloproteinase with thrombospondin motifs 5
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ATS5_HUMANQ9UNA0ENSG0000015473611096Hs.58324605007

Functions and classifications

GOC:cytoplasm, C:nucleus, C:proteinaceous extracellular matrix, F:integrin binding, F:metalloendopeptidase activity, F:metallopeptidase activity, F:zinc ion binding, P:proteolysis, F:metal ion binding
UniProt3D-structure, Cleavage on pair of basic residues, Complete proteome, Disulfide bond, Extracellular matrix, Glycoprotein, Hydrolase, Metal-binding, Metalloprotease, Polymorphism, Protease, Reference proteome, Repeat, Secreted, Signal, Zinc, Zymogen
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.270.00185RNA microarray19698090
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.1< 0.05RNA microarray21752957
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.482.37E-03RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium