CKDdb-logoCKDdb - Molecule ID A438F

geneAdamts4
nameA disintegrin and metalloproteinase with thrombospondin motifs 4
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGene
ATS4_MOUSEQ8BNJ2ENSMUSG00000006403240913Mm.491147

Functions and classifications

GOC:proteinaceous extracellular matrix, F:metalloendopeptidase activity, F:metallopeptidase activity, F:protein binding, F:zinc ion binding, P:defense response to bacterium, P:proteolysis, C:extracellular space, C:proteinaceous extracellular matrix, F:metalloendopeptidase activity, F:metallopeptidase activity, F:protein binding, F:zinc ion binding, P:defense response to bacterium, P:proteolysis, C:proteinaceous extracellular matrix, F:metalloendopeptidase activity, F:metallopeptidase activity, F:protein binding, F:zinc ion binding, P:defense response to bacterium, P:proteolysis, C:proteinaceous extracellular matrix, F:metalloendopeptidase activity, F:metallopeptidase activity, F:protein binding, F:zinc ion binding, P:defense response to bacterium, P:proteolysis, C:extracellular space, F:metalloendopeptidase activity, F:metallopeptidase activity, F:protein binding, P:defense response to bacterium, P:proteolysis, C:proteinaceous extracellular matrix, F:metalloendopeptidase activity, F:metallopeptidase activity, F:protein binding, F:zinc ion binding, P:defense response to bacterium, P:proteolysis
UniProtCleavage on pair of basic residues, Complete proteome, Disulfide bond, Extracellular matrix, Glycoprotein, Hydrolase, Metal-binding, Metalloprotease, Protease, Reference proteome, Secreted, Signal, Zinc, Zymogen
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp23757392bRattus norvegicus13kidneywholeDiabetes (diabetic nephropathy)3.31< 0.05RNA-seq23757392
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)2.280.0000311RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium