CKDdb-logoCKDdb - Molecule ID A4068

geneBUB3
nameMitotic checkpoint protein BUB3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BUB3_HUMANO43684ENSP000003578519184Hs.418533603719

Functions and classifications

GOC:condensed chromosome kinetochore, C:cytosol, C:kinetochore, C:nucleus, P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, P:attachment of spindle microtubules to kinetochore, P:meiosis, P:mitotic sister chromatid segregation, P:mitotic spindle assembly checkpoint, P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:regulation of chromosome segregation, P:spindle assembly checkpoint, P:cell division, P:mitotic cell cycle spindle assembly checkpoint, P:mitotic prometaphase
UniProtAcetylation, ADP-ribosylation, Alternative splicing, Cell cycle, Cell division, Centromere, Chromosome, Chromosome partition, Complete proteome, Isopeptide bond, Kinetochore, Meiosis, Mitosis, Nucleus, Phosphoprotein, Reference proteome, Repeat, Ubl conjugation, WD repeat
PADBCC: cell cycle (turnover, mitosis, meiosis)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.89< 0.05RNA microarray21752957
Exp22061828Rattus norvegicus kidney Gentamicin_induced (Gentamicin-induced nephropathy)2.735.50E-06Nano RP-LC, MALDI-TOF22061828
Exp24172336Mus musculus6kidneycortexAKI (AKI)10000.001736533LC-MS/MS24172336
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.497.17E-04RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium