CKDdb-logoCKDdb - Molecule ID A4060

geneASPM, MCPH5
nameAbnormal spindles
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ASPM_HUMANQ8IZT6ENSG00000066279259266Hs.121028605481, 608716

Functions and classifications

GOC:cytoplasm, C:midbody, C:nucleus, C:spindle pole, P:developmental growth, P:forebrain neuroblast division, P:maintenance of centrosome location, P:mitosis, P:negative regulation of asymmetric cell division, P:negative regulation of neuron differentiation, P:neuron migration, P:oogenesis, P:positive regulation of canonical Wnt signaling pathway, P:positive regulation of neuroblast proliferation, P:spermatogenesis, P:positive regulation of canonical Wnt receptor signaling pathway
UniProtAlternative splicing, Calmodulin-binding, Cell cycle, Cell division, Coiled coil, Complete proteome, Cytoplasm, Cytoskeleton, Mitosis, Nucleus, Phosphoprotein, Polymorphism, Primary microcephaly, Reference proteome, Repeat
PADBcell cycle (turnover, mitosis, meiosis)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)2.360.0198116RNA microarray23935909
Exp25133636Homo sapiens22kidneyglomeruliGlomerulonephritis (IgA nephropathy (with endocapillary proliferation (E1)))2.10RNA microarray25133636
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.282.60E-03RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.140.013999RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.160.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium