CKDdb-logoCKDdb - Molecule ID A4054

geneALOX5AP, FLAP
nameArachidonate 5-lipoxygenase-activating protein
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AL5AP_HUMANP20292ENSG00000132965241Hs.507658601367, 603700, 608557

Functions and classifications

GOC:cytosol, C:endoplasmic reticulum, C:endoplasmic reticulum membrane, C:integral component of membrane, C:nuclear membrane, F:arachidonic acid binding, F:enzyme activator activity, P:arachidonic acid metabolic process, P:cellular response to calcium ion, P:leukotriene biosynthetic process, P:leukotriene production involved in inflammatory response, P:lipoxin metabolic process, P:lipoxygenase pathway, P:positive regulation of acute inflammatory response, P:positive regulation of catalytic activity, P:protein homotrimerization, C:integral to membrane, F:arachidonate 5-lipoxygenase activity, F:glutathione peroxidase activity, F:glutathione transferase activity, P:glutathione biosynthetic process
UniProt3D-structure, Complete proteome, Endoplasmic reticulum, Leukotriene biosynthesis, Membrane, Nucleus, Reference proteome, Transmembrane, Transmembrane helix
PADBcell cycle (turnover, mitosis, meiosis)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17327501aMus musculus6kidneywholeIAKI (Ischemic acute kidney injury)7.46< 0.05RNA microarray17327501
Exp17327501bMus musculus6kidneywholeIAKI (Ischemic acute kidney injury)2646.74< 0.05RNA microarray17327501
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)8< 0.05RNA microarray18187931
Exp18187931bMus musculus18kidneyglomeruliGlomerulonephritis (lupus nephritis)4.6< 0.05RNA microarray18187931
Exp18354378Homo sapiens8kidneyepithelial cellsureteral_obstruction (unilateral ureteral obstruction)0.248 +/- 1.11< 0.05RNA microarray18354378
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.331.47E-08RNA microarray19698090
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)2.86< 0.05RNA microarray21752957
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2.86< 0.05RNA-seq23757392
Exp25133636Homo sapiens22kidneyglomeruliGlomerulonephritis (IgA nephropathy (with endocapillary proliferation (E1)))2.040.0487RNA microarray25133636

Compile date 08-10-2018© iMODE-CKD consortium