CKDdb-logoCKDdb - Molecule ID A3876

geneADD1, ADDA
nameAlpha adducin
speciesHomo sapiens

Molecule reference


Functions and classifications

GOC:cytosol, C:dendritic spine, C:F-actin capping protein complex, C:nucleus, C:perinuclear region of cytoplasm, C:plasma membrane, C:postsynaptic density, F:actin filament binding, F:spectrin binding, F:structural molecule activity, P:actin filament bundle assembly, P:activation of signaling protein activity involved in unfolded protein response, P:barbed-end actin filament capping, P:cell morphogenesis, P:cell volume homeostasis, P:cellular component disassembly involved in execution phase of apoptosis, P:cellular protein metabolic process, P:cellular response to retinoic acid, P:erythrocyte differentiation, P:hemoglobin metabolic process, P:homeostasis of number of cells within a tissue, P:in utero embryonic development, P:multicellular organism growth, P:positive regulation of angiogenesis, P:positive regulation of endocytosis, P:positive regulation of protein binding, C:membrane, P:negative regulation of actin filament polymerization, C:cytoskeleton, F:calmodulin binding, P:cytoskeleton organization, C:synapse, F:metal ion binding
UniProtAcetylation, Actin-binding, Alternative splicing, Calmodulin-binding, Cell membrane, Complete proteome, Cytoplasm, Cytoskeleton, Direct protein sequencing, Membrane, Phosphoprotein, Polymorphism, Reference proteome
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)6.922.88E-06RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)5.610.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium