CKDdb-logoCKDdb - Molecule ID A3874

geneANK3
nameAnkyrin 3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ANK3_HUMANQ12955ENSG00000151150288Hs.499725600465

Functions and classifications

GOC:axon initial segment, C:basolateral plasma membrane, C:cell surface, C:costamere, C:dendrite, C:intercalated disc, C:lateral plasma membrane, C:lysosome, C:neuromuscular junction, C:node of Ranvier, C:paranode region of axon, C:postsynaptic membrane, C:sarcoplasmic reticulum, C:spectrin-associated cytoskeleton, C:T-tubule, C:Z disc, F:cadherin binding, F:ion channel binding, F:protein binding, bridging, F:spectrin binding, F:structural constituent of cytoskeleton, P:axon guidance, P:axonogenesis, P:Golgi to plasma membrane protein transport, P:maintenance of protein location in plasma membrane, P:membrane assembly, P:mitotic cytokinesis, P:neuromuscular junction development, P:positive regulation of cell communication by electrical coupling, P:positive regulation of gene expression, P:positive regulation of homotypic cell-cell adhesion, P:positive regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential, P:positive regulation of membrane potential, P:positive regulation of protein targeting to membrane, P:positive regulation of sodium ion transmembrane transporter activity, P:positive regulation of sodium ion transport, P:protein targeting to plasma membrane, P:regulation of action potential in neuron, P:regulation of potassium ion transport, P:signal transduction, P:signal transduction, C:axon initial segment, C:endoplasmic reticulum, C:Golgi apparatus, P:cytoskeletal anchoring at plasma membrane, P:cytokinesis after mitosis, P:synapse organization, C:axon, C:synapse, P:synapse organization
UniProtAlternative splicing, ANK repeat, Cell junction, Cell membrane, Complete proteome, Cytoplasm, Cytoskeleton, Isopeptide bond, Lysosome, Membrane, Phosphoprotein, Polymorphism, Postsynaptic cell membrane, Reference proteome, Repeat, Synapse, Ubl conjugation
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.490cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.460.02cDNA microarray19099603
Exp19845401Mus musculus32eyesretinaDiabetes (diabetic retinopathy)2.04< 0.05LC-MS/MS19845401
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.397.14E-06RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.432.26E-05RNA microarray20019191
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)0.42.10E-06NGS, RNA-seq.22266139
Exp24497609Rattus norvegicus kidneyglomeruliPuromycin_induced (Puromycin nephropathy model)0.71< 0.05LC-MS/MS24497609

Compile date 08-10-2018© iMODE-CKD consortium