CKDdb-logoCKDdb - Molecule ID A3873

nameAnkyrin 2
speciesHomo sapiens

Molecule reference

ANK2_HUMANQ01484ENSG00000145362287Hs.620557106410, 600919

Functions and classifications

GOC:apical plasma membrane, C:basolateral plasma membrane, C:costamere, C:cytoskeleton, C:cytosol, C:integral component of plasma membrane, C:intercalated disc, C:M band, C:membrane raft, C:neuron projection, C:perinuclear region of cytoplasm, C:postsynaptic membrane, C:T-tubule, C:Z disc, F:ATPase binding, F:ion channel binding, F:potassium channel regulator activity, F:protein binding, bridging, F:structural constituent of cytoskeleton, P:atrial septum development, P:axon guidance, P:cardiac muscle contraction, P:cellular calcium ion homeostasis, P:membrane depolarization involved in regulation of SA node cell action potential, P:paranodal junction assembly, P:positive regulation of calcium ion transmembrane transporter activity, P:positive regulation of calcium ion transport, P:positive regulation of cation channel activity, P:positive regulation of gene expression, P:positive regulation of potassium ion transmembrane transporter activity, P:positive regulation of potassium ion transport, P:protein localization to cell surface, P:protein localization to endoplasmic reticulum, P:protein localization to M-band, P:protein localization to T-tubule, P:protein stabilization, P:protein targeting to plasma membrane, P:regulation of atrial cardiac muscle cell action potential, P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, P:regulation of heart rate by cardiac conduction, P:regulation of ventricular cardiac muscle cell action potential, P:regulation of ventricular cardiac muscle cell membrane repolarization, P:response to methylmercury, P:sarcoplasmic reticulum calcium ion transport, P:T-tubule organization, P:signal transduction, P:regulation of cardiac muscle contraction by calcium ion signaling, P:regulation of SA node cell action potential, P:T-tubule organization, C:integral to plasma membrane, P:protein localization to plasma membrane, C:cytoplasm
UniProt3D-structure, Alternative splicing, ANK repeat, Cell junction, Cell membrane, Complete proteome, Cytoplasm, Cytoskeleton, Disease mutation, Long QT syndrome, Membrane, Phosphoprotein, Polymorphism, Postsynaptic cell membrane, Reference proteome, Repeat, Synapse
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)4.350.05RNA microarray17579666
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.40.0482787RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.240.000753RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.283.23E-06RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.393.23E-06RNA microarray20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)down MS/MS, LTQ LX linear ion trap20093355
Exp20485333Homo sapiens20bloodwholeGlomerulonephritis (IgA nephropathy)2.640.009378RNA microarray20485333
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.490.019889449LC-MS/MS24172336
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)6.490.014576RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium