CKDdb-logoCKDdb - Molecule ID A3781

geneAifm1, Aif, Pdcd8
nameApoptosis-inducing factor 1, mitochondrial
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AIFM1_MOUSEQ9Z0X1ENSMUSG0000003693226926Mm.240434300169, 300816, 310490

Functions and classifications

GOC:cytoplasm, C:cytosol, C:mitochondrial inner membrane, C:mitochondrial intermembrane space, C:mitochondrial outer membrane, C:mitochondrion, C:nucleus, C:perinuclear region of cytoplasm, F:DNA binding, F:electron-transferring-flavoprotein dehydrogenase activity, F:FAD binding, F:NAD(P)H oxidase activity, F:protein binding, P:activation of cysteine-type endopeptidase activity involved in apoptotic process, P:apoptotic mitochondrial changes, P:cell redox homeostasis, P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, P:mitochondrial respiratory chain complex I assembly, P:neuron apoptotic process, P:neuron differentiation, P:positive regulation of apoptotic process, P:positive regulation of cell death, P:regulation of apoptotic DNA fragmentation, P:response to oxidative stress, C:cytoplasm, C:cytosol, C:mitochondrial intermembrane space, C:mitochondrial outer membrane, C:mitochondrion, C:nucleus, F:electron-transferring-flavoprotein dehydrogenase activity, F:flavin adenine dinucleotide binding, P:apoptotic mitochondrial changes, P:cell redox homeostasis, P:neuron apoptotic process, P:regulation of apoptotic DNA fragmentation, C:cytoplasm, C:cytosol, C:mitochondrial intermembrane space, C:mitochondrial outer membrane, C:mitochondrion, C:nucleus, F:electron-transferring-flavoprotein dehydrogenase activity, P:apoptotic mitochondrial changes, P:neuron apoptotic process, P:regulation of apoptotic DNA fragmentation, C:mitochondrial intermembrane space, C:nucleus, F:flavin adenine dinucleotide binding, F:oxidoreductase activity, acting on NAD(P)H, P:activation of cysteine-type endopeptidase activity involved in apoptotic process, P:cell redox homeostasis, P:mitochondrial respiratory chain complex I assembly, P:neuron differentiation
UniProt3D-structure, Acetylation, Apoptosis, Complete proteome, Cytoplasm, Direct protein sequencing, DNA-binding, FAD, Flavoprotein, Isopeptide bond, Membrane, Mitochondrion, Mitochondrion inner membrane, NAD, Nucleus, Oxidoreductase, Phosphoprotein, Reference proteome, Transit peptide, Ubl conjugation
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.420.01cDNA microarray19099603
Exp19845401Mus musculus32eyesretinaDiabetes (diabetic retinopathy)3.34< 0.05LC-MS/MS19845401
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.512.26E-05RNA microarray20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)down MS/MS, LTQ LX linear ion trap20093355
Exp20940332Mus musculus kidneycollecting duct cellsVasopressine_induced (Vasopressine in vitro model)0.81< 0.05LC-MS/MS20940332
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.30.000629RNA microarray23291264
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.320.000124RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium