CKDdb-logoCKDdb - Molecule ID A3695

geneACAT2, ACTL
nameCytosolic acetoacetyl-coenzyme A thiolase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
THIC_HUMANQ9BWD1ENSP0000035601539Hs.571037100678

Functions and classifications

GOC:mitochondrion, C:nucleolus, F:acetyl-CoA C-acetyltransferase activity, P:lipid metabolic process, F:transferase activity, transferring acyl groups other than amino-acyl groups, C:mitochondrion, F:transferase activity, transferring acyl groups other than amino-acyl groups
UniProt3D-structure, Acetylation, Acyltransferase, Complete proteome, Cytoplasm, Direct protein sequencing, Polymorphism, Reference proteome, Transferase
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17183245Homo sapiens24kidneyproximal tubuleproteinuria (proteinuric nephropathies)4.53< 0.05cDNA microarrays17183245
Exp19369687Mus musculus kidneyproximal tubule cellsCyclosporine_A_induced (Ciclosporine A in vitro model)0.41< 0.04MALDI TOF/TOF19369687
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)up MS/MS, LTQ LX linear ion trap20093355

Compile date 08-10-2018© iMODE-CKD consortium